4K9D
X-ray crystal structure of a Glyceraldehyde 3-phosphate dehydrogenase from Brugia malayi bound to the co-factor NAD
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006006 | biological_process | glucose metabolic process |
A | 0006096 | biological_process | glycolytic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
B | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006006 | biological_process | glucose metabolic process |
B | 0006096 | biological_process | glycolytic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
C | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006006 | biological_process | glucose metabolic process |
C | 0006096 | biological_process | glycolytic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
C | 0050661 | molecular_function | NADP binding |
C | 0051287 | molecular_function | NAD binding |
D | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006006 | biological_process | glucose metabolic process |
D | 0006096 | biological_process | glycolytic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
D | 0050661 | molecular_function | NADP binding |
D | 0051287 | molecular_function | NAD binding |
E | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006006 | biological_process | glucose metabolic process |
E | 0006096 | biological_process | glycolytic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
E | 0050661 | molecular_function | NADP binding |
E | 0051287 | molecular_function | NAD binding |
F | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006006 | biological_process | glucose metabolic process |
F | 0006096 | biological_process | glycolytic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
F | 0050661 | molecular_function | NADP binding |
F | 0051287 | molecular_function | NAD binding |
G | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0006006 | biological_process | glucose metabolic process |
G | 0006096 | biological_process | glycolytic process |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
G | 0050661 | molecular_function | NADP binding |
G | 0051287 | molecular_function | NAD binding |
H | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
H | 0005737 | cellular_component | cytoplasm |
H | 0005829 | cellular_component | cytosol |
H | 0006006 | biological_process | glucose metabolic process |
H | 0006096 | biological_process | glycolytic process |
H | 0016491 | molecular_function | oxidoreductase activity |
H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
H | 0050661 | molecular_function | NADP binding |
H | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NAD A 401 |
Chain | Residue |
A | ASN9 |
A | PHE37 |
A | ILE38 |
A | SER83 |
A | LYS84 |
A | SER102 |
A | THR103 |
A | GLY104 |
A | SER126 |
A | ALA127 |
A | CYS157 |
A | GLY10 |
A | ALA188 |
A | ASN321 |
A | TYR325 |
A | HOH502 |
A | HOH504 |
A | HOH510 |
A | HOH511 |
A | HOH574 |
A | HOH586 |
A | HOH594 |
A | PHE11 |
A | HOH628 |
A | GLY12 |
A | ARG13 |
A | ILE14 |
A | ASN34 |
A | ASP35 |
A | PRO36 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 402 |
Chain | Residue |
A | PRO133 |
A | MET134 |
A | LYS224 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 403 |
Chain | Residue |
A | ARG20 |
A | HIS53 |
A | GLY293 |
A | TYR323 |
site_id | AC4 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NAD B 401 |
Chain | Residue |
B | ASN9 |
B | GLY10 |
B | GLY12 |
B | ARG13 |
B | ILE14 |
B | ASP35 |
B | PRO36 |
B | PHE37 |
B | SER83 |
B | LYS84 |
B | SER102 |
B | THR103 |
B | GLY104 |
B | SER126 |
B | ALA127 |
B | CYS157 |
B | ALA188 |
B | ASN321 |
B | TYR325 |
B | HOH501 |
B | HOH502 |
B | HOH520 |
B | HOH521 |
B | HOH522 |
B | HOH523 |
B | HOH528 |
B | HOH550 |
B | HOH617 |
B | HOH618 |
B | HOH626 |
B | HOH642 |
B | HOH643 |
B | HOH660 |
B | HOH670 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 402 |
Chain | Residue |
B | ARG20 |
B | HIS53 |
B | GLY293 |
B | TYR323 |
site_id | AC6 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAD C 401 |
Chain | Residue |
C | HOH573 |
C | HOH587 |
C | HOH626 |
F | HOH617 |
C | ASN9 |
C | GLY10 |
C | GLY12 |
C | ARG13 |
C | ILE14 |
C | ASN34 |
C | ASP35 |
C | PRO36 |
C | PHE37 |
C | SER83 |
C | LYS84 |
C | SER102 |
C | THR103 |
C | GLY104 |
C | PHE106 |
C | SER126 |
C | ALA127 |
C | ALA188 |
C | ASN321 |
C | TYR325 |
C | HOH502 |
C | HOH521 |
C | HOH538 |
C | HOH540 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO C 402 |
Chain | Residue |
C | ARG20 |
C | HIS53 |
C | TYR323 |
C | HOH543 |
site_id | AC8 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE NAD D 500 |
Chain | Residue |
D | ASN9 |
D | GLY10 |
D | PHE11 |
D | GLY12 |
D | ARG13 |
D | ILE14 |
D | ASN34 |
D | ASP35 |
D | PRO36 |
D | PHE37 |
D | ILE38 |
D | LYS84 |
D | SER102 |
D | THR103 |
D | GLY104 |
D | PHE106 |
D | SER126 |
D | ALA127 |
D | ALA188 |
D | ASN321 |
D | TYR325 |
D | HOH601 |
D | HOH602 |
D | HOH604 |
D | HOH605 |
D | HOH628 |
D | HOH661 |
D | HOH668 |
D | HOH669 |
D | HOH686 |
D | HOH687 |
site_id | AC9 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAD E 500 |
Chain | Residue |
E | ASN9 |
E | GLY10 |
E | GLY12 |
E | ARG13 |
E | ILE14 |
E | ASP35 |
E | PRO36 |
E | PHE37 |
E | LYS84 |
E | SER102 |
E | THR103 |
E | GLY104 |
E | SER126 |
E | CYS157 |
E | ALA188 |
E | ASN321 |
E | HOH622 |
E | HOH642 |
E | HOH658 |
H | PRO196 |
site_id | BC1 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAD F 401 |
Chain | Residue |
F | ASN9 |
F | GLY10 |
F | GLY12 |
F | ARG13 |
F | ILE14 |
F | ASP35 |
F | PRO36 |
F | PHE37 |
F | SER83 |
F | LYS84 |
F | SER102 |
F | THR103 |
F | GLY104 |
F | SER126 |
F | ALA127 |
F | ALA188 |
F | ASN321 |
F | TYR325 |
F | HOH519 |
F | HOH521 |
F | HOH531 |
F | HOH532 |
F | HOH533 |
F | HOH547 |
F | HOH612 |
F | HOH616 |
F | HOH630 |
F | HOH642 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO F 402 |
Chain | Residue |
F | ARG20 |
F | HIS53 |
F | GLY293 |
site_id | BC3 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NAD G 401 |
Chain | Residue |
G | ASN9 |
G | GLY10 |
G | PHE11 |
G | GLY12 |
G | ARG13 |
G | ILE14 |
G | ASN34 |
G | ASP35 |
G | PRO36 |
G | PHE37 |
G | LYS84 |
G | SER102 |
G | THR103 |
G | GLY104 |
G | PHE106 |
G | SER126 |
G | ALA127 |
G | ALA188 |
G | ASN321 |
G | TYR325 |
G | HOH522 |
G | HOH523 |
G | HOH537 |
G | HOH562 |
G | HOH564 |
G | HOH567 |
G | HOH611 |
G | HOH666 |
G | HOH668 |
G | HOH670 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO G 402 |
Chain | Residue |
G | PRO133 |
G | MET134 |
G | LYS224 |
G | HOH648 |
site_id | BC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE NAD H 500 |
Chain | Residue |
E | PRO196 |
H | ASN9 |
H | GLY12 |
H | ARG13 |
H | ILE14 |
H | ASP35 |
H | PRO36 |
H | PHE37 |
H | ILE38 |
H | LYS84 |
H | SER102 |
H | GLY104 |
H | SER126 |
H | ALA127 |
H | ALA188 |
H | ASN321 |
H | TYR325 |
H | HOH614 |
Functional Information from PROSITE/UniProt
site_id | PS00071 |
Number of Residues | 8 |
Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
Chain | Residue | Details |
A | ALA155-LEU162 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10009 |
Chain | Residue | Details |
A | CYS157 | |
B | CYS157 | |
C | CYS157 | |
D | CYS157 | |
E | CYS157 | |
F | CYS157 | |
G | CYS157 | |
H | CYS157 |
site_id | SWS_FT_FI2 |
Number of Residues | 64 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ARG13 | |
B | ASP35 | |
B | LYS84 | |
B | SER156 | |
B | THR187 | |
B | THR216 | |
B | ARG239 | |
B | ASN321 | |
C | ARG13 | |
C | ASP35 | |
C | LYS84 | |
A | ASP35 | |
C | SER156 | |
C | THR187 | |
C | THR216 | |
C | ARG239 | |
C | ASN321 | |
D | ARG13 | |
D | ASP35 | |
D | LYS84 | |
D | SER156 | |
D | THR187 | |
A | LYS84 | |
D | THR216 | |
D | ARG239 | |
D | ASN321 | |
E | ARG13 | |
E | ASP35 | |
E | LYS84 | |
E | SER156 | |
E | THR187 | |
E | THR216 | |
E | ARG239 | |
A | SER156 | |
E | ASN321 | |
F | ARG13 | |
F | ASP35 | |
F | LYS84 | |
F | SER156 | |
F | THR187 | |
F | THR216 | |
F | ARG239 | |
F | ASN321 | |
G | ARG13 | |
A | THR187 | |
G | ASP35 | |
G | LYS84 | |
G | SER156 | |
G | THR187 | |
G | THR216 | |
G | ARG239 | |
G | ASN321 | |
H | ARG13 | |
H | ASP35 | |
H | LYS84 | |
A | THR216 | |
H | SER156 | |
H | THR187 | |
H | THR216 | |
H | ARG239 | |
H | ASN321 | |
A | ARG239 | |
A | ASN321 | |
B | ARG13 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | SITE: Activates thiol group during catalysis => ECO:0000250 |
Chain | Residue | Details |
A | HIS184 | |
B | HIS184 | |
C | HIS184 | |
D | HIS184 | |
E | HIS184 | |
F | HIS184 | |
G | HIS184 | |
H | HIS184 |