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4K8N

Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 18:1 Ceramide-1-Phosphate (18:1-C1P)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005543molecular_functionphospholipid binding
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0008289molecular_functionlipid binding
A0010008cellular_componentendosome membrane
A0010507biological_processnegative regulation of autophagy
A0032691biological_processnegative regulation of interleukin-1 beta production
A0035627biological_processceramide transport
A0046836biological_processglycolipid transport
A0120009biological_processintermembrane lipid transfer
A0120013molecular_functionlipid transfer activity
A1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
A1902387molecular_functionceramide 1-phosphate binding
A1902388molecular_functionceramide 1-phosphate transfer activity
A1902389biological_processceramide 1-phosphate transport
B0005543molecular_functionphospholipid binding
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0008289molecular_functionlipid binding
B0010008cellular_componentendosome membrane
B0010507biological_processnegative regulation of autophagy
B0032691biological_processnegative regulation of interleukin-1 beta production
B0035627biological_processceramide transport
B0046836biological_processglycolipid transport
B0120009biological_processintermembrane lipid transfer
B0120013molecular_functionlipid transfer activity
B1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
B1902387molecular_functionceramide 1-phosphate binding
B1902388molecular_functionceramide 1-phosphate transfer activity
B1902389biological_processceramide 1-phosphate transport
C0005543molecular_functionphospholipid binding
C0005634cellular_componentnucleus
C0005640cellular_componentnuclear outer membrane
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006869biological_processlipid transport
C0008289molecular_functionlipid binding
C0010008cellular_componentendosome membrane
C0010507biological_processnegative regulation of autophagy
C0032691biological_processnegative regulation of interleukin-1 beta production
C0035627biological_processceramide transport
C0046836biological_processglycolipid transport
C0120009biological_processintermembrane lipid transfer
C0120013molecular_functionlipid transfer activity
C1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
C1902387molecular_functionceramide 1-phosphate binding
C1902388molecular_functionceramide 1-phosphate transfer activity
C1902389biological_processceramide 1-phosphate transport
D0005543molecular_functionphospholipid binding
D0005634cellular_componentnucleus
D0005640cellular_componentnuclear outer membrane
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006869biological_processlipid transport
D0008289molecular_functionlipid binding
D0010008cellular_componentendosome membrane
D0010507biological_processnegative regulation of autophagy
D0032691biological_processnegative regulation of interleukin-1 beta production
D0035627biological_processceramide transport
D0046836biological_processglycolipid transport
D0120009biological_processintermembrane lipid transfer
D0120013molecular_functionlipid transfer activity
D1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
D1902387molecular_functionceramide 1-phosphate binding
D1902388molecular_functionceramide 1-phosphate transfer activity
D1902389biological_processceramide 1-phosphate transport
E0005543molecular_functionphospholipid binding
E0005634cellular_componentnucleus
E0005640cellular_componentnuclear outer membrane
E0005737cellular_componentcytoplasm
E0005768cellular_componentendosome
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006869biological_processlipid transport
E0008289molecular_functionlipid binding
E0010008cellular_componentendosome membrane
E0010507biological_processnegative regulation of autophagy
E0032691biological_processnegative regulation of interleukin-1 beta production
E0035627biological_processceramide transport
E0046836biological_processglycolipid transport
E0120009biological_processintermembrane lipid transfer
E0120013molecular_functionlipid transfer activity
E1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
E1902387molecular_functionceramide 1-phosphate binding
E1902388molecular_functionceramide 1-phosphate transfer activity
E1902389biological_processceramide 1-phosphate transport
F0005543molecular_functionphospholipid binding
F0005634cellular_componentnucleus
F0005640cellular_componentnuclear outer membrane
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006869biological_processlipid transport
F0008289molecular_functionlipid binding
F0010008cellular_componentendosome membrane
F0010507biological_processnegative regulation of autophagy
F0032691biological_processnegative regulation of interleukin-1 beta production
F0035627biological_processceramide transport
F0046836biological_processglycolipid transport
F0120009biological_processintermembrane lipid transfer
F0120013molecular_functionlipid transfer activity
F1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
F1902387molecular_functionceramide 1-phosphate binding
F1902388molecular_functionceramide 1-phosphate transfer activity
F1902389biological_processceramide 1-phosphate transport
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 1Q0 A 301
ChainResidue
APHE50
ALEU118
AHIS150
AVAL158
APHE171
EPRO151
ETRP152
EVAL153
AILE53
AASP56
ALYS60
AARG97
AARG106
AARG110
AALA114
ATRP117

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 1Q0 B 301
ChainResidue
BLEU39
BILE53
BASP56
BLYS60
BARG106
BTRP117
BHIS150
BVAL154
CPRO151
CVAL153

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 1Q0 C 301
ChainResidue
BTRP152
BARG155
CTRP36
CPHE42
CASP56
CLYS60
CARG97
CARG106
CARG110
CALA114
CTRP117
CLEU118
CHIS150
CLEU165

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 1Q0 D 301
ChainResidue
DTRP36
DLEU43
DPHE50
DILE53
DASP56
DLYS60
DARG106
DARG110
DALA114
DTRP117
DLEU122
DPHE171
FVAL153

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 1Q0 E 301
ChainResidue
ETRP36
ELEU39
EPHE42
EILE53
EASP56
ELYS60
EARG106
EALA114
ETRP117
ECYS138
EHIS150
EVAL154
EMET175

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 1Q0 F 301
ChainResidue
DPRO151
DVAL153
FASP56
FLYS60
FARG106
FARG110
FHIS150

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues30
DetailsBINDING: BINDING => ECO:0000269|PubMed:23863933
ChainResidueDetails
AASP56
BHIS150
CASP56
CLYS60
CARG106
CARG110
CHIS150
DASP56
DLYS60
DARG106
DARG110
ALYS60
DHIS150
EASP56
ELYS60
EARG106
EARG110
EHIS150
FASP56
FLYS60
FARG106
FARG110
AARG106
FHIS150
AARG110
AHIS150
BASP56
BLYS60
BARG106
BARG110

224004

PDB entries from 2024-08-21

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