4K87
Crystal structure of human prolyl-tRNA synthetase (substrate bound form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 601 |
| Chain | Residue |
| A | CYS448 |
| A | CYS453 |
| A | CYS495 |
| A | CYS497 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADN A 602 |
| Chain | Residue |
| A | GLN237 |
| A | GLY239 |
| A | THR240 |
| A | GLY274 |
| A | THR276 |
| A | ARG278 |
| A | PRO603 |
| A | HOH764 |
| A | ARG152 |
| A | PHE161 |
| A | LEU162 |
| A | ARG163 |
| A | THR164 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PRO A 603 |
| Chain | Residue |
| A | THR121 |
| A | GLU123 |
| A | ARG152 |
| A | TRP169 |
| A | GLU171 |
| A | HIS173 |
| A | PHE216 |
| A | HIS242 |
| A | SER272 |
| A | TRP273 |
| A | ADN602 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29273753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29273753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
