Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4K85

Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 12:0 Ceramide-1-Phosphate (12:0-C1P)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005543molecular_functionphospholipid binding
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0008289molecular_functionlipid binding
A0010008cellular_componentendosome membrane
A0010507biological_processnegative regulation of autophagy
A0032588cellular_componenttrans-Golgi network membrane
A0032691biological_processnegative regulation of interleukin-1 beta production
A0035627biological_processceramide transport
A0046836biological_processglycolipid transport
A0120009biological_processintermembrane lipid transfer
A0120013molecular_functionlipid transfer activity
A1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
A1902387molecular_functionceramide 1-phosphate binding
A1902388molecular_functionceramide 1-phosphate transfer activity
A1902389biological_processceramide 1-phosphate transport
B0005543molecular_functionphospholipid binding
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0008289molecular_functionlipid binding
B0010008cellular_componentendosome membrane
B0010507biological_processnegative regulation of autophagy
B0032588cellular_componenttrans-Golgi network membrane
B0032691biological_processnegative regulation of interleukin-1 beta production
B0035627biological_processceramide transport
B0046836biological_processglycolipid transport
B0120009biological_processintermembrane lipid transfer
B0120013molecular_functionlipid transfer activity
B1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
B1902387molecular_functionceramide 1-phosphate binding
B1902388molecular_functionceramide 1-phosphate transfer activity
B1902389biological_processceramide 1-phosphate transport
C0005543molecular_functionphospholipid binding
C0005640cellular_componentnuclear outer membrane
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006869biological_processlipid transport
C0008289molecular_functionlipid binding
C0010008cellular_componentendosome membrane
C0010507biological_processnegative regulation of autophagy
C0032588cellular_componenttrans-Golgi network membrane
C0032691biological_processnegative regulation of interleukin-1 beta production
C0035627biological_processceramide transport
C0046836biological_processglycolipid transport
C0120009biological_processintermembrane lipid transfer
C0120013molecular_functionlipid transfer activity
C1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
C1902387molecular_functionceramide 1-phosphate binding
C1902388molecular_functionceramide 1-phosphate transfer activity
C1902389biological_processceramide 1-phosphate transport
D0005543molecular_functionphospholipid binding
D0005640cellular_componentnuclear outer membrane
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006869biological_processlipid transport
D0008289molecular_functionlipid binding
D0010008cellular_componentendosome membrane
D0010507biological_processnegative regulation of autophagy
D0032588cellular_componenttrans-Golgi network membrane
D0032691biological_processnegative regulation of interleukin-1 beta production
D0035627biological_processceramide transport
D0046836biological_processglycolipid transport
D0120009biological_processintermembrane lipid transfer
D0120013molecular_functionlipid transfer activity
D1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
D1902387molecular_functionceramide 1-phosphate binding
D1902388molecular_functionceramide 1-phosphate transfer activity
D1902389biological_processceramide 1-phosphate transport
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE 1PZ A 301
ChainResidue
ALEU43
AHIS150
AVAL154
APHE162
AHOH428
AHOH466
AHOH476
AHOH479
AHOH481
AHOH506
BVAL153
AILE53
AASP56
AVAL57
ALYS60
AARG106
AARG110
ATRP117
ALEU118

site_idAC2
Number of Residues21
DetailsBINDING SITE FOR RESIDUE 1PZ B 301
ChainResidue
AILE49
AVAL153
BLEU43
BILE53
BASP56
BLYS60
BARG106
BARG110
BALA114
BTRP117
BPHE121
BLEU146
BHIS150
BVAL153
BHOH412
BHOH418
BHOH448
BHOH456
BHOH462
BHOH465
BHOH555

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 1PZ C 301
ChainResidue
CILE53
CASP56
CLYS60
CARG106
CARG110
CALA114
CTRP117
CCYS138
CHIS150
CHOH449
CHOH459
CHOH469
CHOH471
CHOH534
DILE49
DPHE50
DVAL153
DALA157

site_idAC4
Number of Residues20
DetailsBINDING SITE FOR RESIDUE 1PZ D 301
ChainResidue
CVAL153
DPHE42
DLEU46
DPHE50
DILE53
DASP56
DLYS60
DARG106
DARG110
DTRP117
DTYR142
DLEU146
DHIS150
DPHE171
DHOH416
DHOH433
DHOH458
DHOH460
DHOH487
DHOH524

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23863933","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

PDB statisticsPDBj update infoContact PDBjnumon