4K84

Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 16:0 ceramide-1-phosphate (16:0-C1P)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005543	molecular_function	phospholipid binding
A	0005640	cellular_component	nuclear outer membrane
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0010008	cellular_component	endosome membrane
A	0010507	biological_process	negative regulation of autophagy
A	0032588	cellular_component	trans-Golgi network membrane
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0035627	biological_process	ceramide transport
A	0046836	biological_process	glycolipid transport
A	0120009	biological_process	intermembrane lipid transfer
A	0120013	molecular_function	lipid transfer activity
A	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
A	1902387	molecular_function	ceramide 1-phosphate binding
A	1902388	molecular_function	ceramide 1-phosphate transfer activity
A	1902389	biological_process	ceramide 1-phosphate transport
B	0005543	molecular_function	phospholipid binding
B	0005640	cellular_component	nuclear outer membrane
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0010008	cellular_component	endosome membrane
B	0010507	biological_process	negative regulation of autophagy
B	0032588	cellular_component	trans-Golgi network membrane
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0035627	biological_process	ceramide transport
B	0046836	biological_process	glycolipid transport
B	0120009	biological_process	intermembrane lipid transfer
B	0120013	molecular_function	lipid transfer activity
B	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
B	1902387	molecular_function	ceramide 1-phosphate binding
B	1902388	molecular_function	ceramide 1-phosphate transfer activity
B	1902389	biological_process	ceramide 1-phosphate transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1PX A 301

Chain	Residue
A	LEU10
A	TRP117
A	LEU146
A	HIS150
A	PHE162
A	MET175
A	HOH415
A	HOH424
A	HOH481
A	PHE42
A	LEU46
A	PHE52
A	ASP56
A	LYS60
A	ARG106
A	ARG110
A	ALA114

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site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1PX B 301

Chain	Residue
B	LEU10
B	PHE42
B	LEU46
B	ILE53
B	ASP56
B	VAL57
B	LYS60
B	ARG106
B	ARG110
B	ALA114
B	TRP117
B	LEU118
B	LEU146
B	HIS150
B	PHE162
B	HOH415
B	HOH435
B	HOH469
B	HOH553
B	HOH584
B	HOH587

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23863933","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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