4K73

X-ray crystal structure of an L,D-transpeptidase from Mycobacterium tuberculosis H37Rv

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008360	biological_process	regulation of cell shape
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0018104	biological_process	peptidoglycan-protein cross-linking
A	0071555	biological_process	cell wall organization
A	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	VAL48
A	ASP262
A	HOH403
A	HOH406
A	HOH410
A	HOH421

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373

Chain	Residue	Details
A	HIS228

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373

Chain	Residue	Details
A	CYS246

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Binds to carbapenem drug (covalent) => ECO:0000250

Chain	Residue	Details
A	CYS246

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