4K6F
X-ray crystal structure of a putative Acetoacetyl-CoA reductase from Burkholderia cenocepacia bound to the co-factor NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| A | 0032787 | biological_process | monocarboxylic acid metabolic process |
| A | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| B | 0032787 | biological_process | monocarboxylic acid metabolic process |
| B | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| C | 0032787 | biological_process | monocarboxylic acid metabolic process |
| C | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| D | 0032787 | biological_process | monocarboxylic acid metabolic process |
| D | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NAP B 300 |
| Chain | Residue |
| A | ARG77 |
| B | GLY90 |
| B | ILE91 |
| B | THR111 |
| B | HOH485 |
| B | HOH524 |
| B | GLY10 |
| B | TYR34 |
| B | SER35 |
| B | ASN38 |
| B | VAL60 |
| B | ASP61 |
| B | VAL62 |
| B | ALA89 |
| site_id | AC2 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP C 300 |
| Chain | Residue |
| C | GLY10 |
| C | GLY13 |
| C | GLY14 |
| C | LEU15 |
| C | TYR34 |
| C | SER35 |
| C | ASN38 |
| C | VAL60 |
| C | ASP61 |
| C | VAL62 |
| C | ASN88 |
| C | ALA89 |
| C | GLY90 |
| C | ILE91 |
| C | THR111 |
| C | SER139 |
| C | TYR153 |
| C | LYS157 |
| C | PRO183 |
| C | GLY184 |
| C | LEU186 |
| C | THR188 |
| C | HOH402 |
| C | HOH413 |
| C | HOH423 |
| C | HOH446 |
| C | HOH483 |
| C | HOH489 |
| C | HOH492 |
| C | HOH494 |
| C | HOH517 |
| C | HOH519 |
| C | HOH525 |
| C | HOH538 |
| C | HOH561 |
| C | HOH575 |
| C | HOH641 |
| site_id | AC3 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP D 300 |
| Chain | Residue |
| D | GLY10 |
| D | GLY13 |
| D | GLY14 |
| D | LEU15 |
| D | TYR34 |
| D | SER35 |
| D | ASN38 |
| D | VAL60 |
| D | ASP61 |
| D | VAL62 |
| D | ASN88 |
| D | ALA89 |
| D | GLY90 |
| D | ILE91 |
| D | THR111 |
| D | SER139 |
| D | TYR153 |
| D | LYS157 |
| D | PRO183 |
| D | GLY184 |
| D | LEU186 |
| D | THR188 |
| D | HOH410 |
| D | HOH430 |
| D | HOH480 |
| D | HOH503 |
| D | HOH506 |
| D | HOH521 |
| D | HOH535 |
| D | HOH537 |
| D | HOH542 |
| D | HOH547 |
| D | HOH574 |
| D | HOH582 |
| D | HOH625 |
| D | HOH651 |
| D | HOH670 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvngskgsvgQtnYAAAKAGMhGFTkSLA |
| Chain | Residue | Details |
| A | SER140-ALA168 |
