4K6F
X-ray crystal structure of a putative Acetoacetyl-CoA reductase from Burkholderia cenocepacia bound to the co-factor NADP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
A | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
B | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
C | 0000166 | molecular_function | nucleotide binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
C | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
D | 0000166 | molecular_function | nucleotide binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
D | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE NAP B 300 |
Chain | Residue |
A | ARG77 |
B | GLY90 |
B | ILE91 |
B | THR111 |
B | HOH485 |
B | HOH524 |
B | GLY10 |
B | TYR34 |
B | SER35 |
B | ASN38 |
B | VAL60 |
B | ASP61 |
B | VAL62 |
B | ALA89 |
site_id | AC2 |
Number of Residues | 37 |
Details | BINDING SITE FOR RESIDUE NAP C 300 |
Chain | Residue |
C | GLY10 |
C | GLY13 |
C | GLY14 |
C | LEU15 |
C | TYR34 |
C | SER35 |
C | ASN38 |
C | VAL60 |
C | ASP61 |
C | VAL62 |
C | ASN88 |
C | ALA89 |
C | GLY90 |
C | ILE91 |
C | THR111 |
C | SER139 |
C | TYR153 |
C | LYS157 |
C | PRO183 |
C | GLY184 |
C | LEU186 |
C | THR188 |
C | HOH402 |
C | HOH413 |
C | HOH423 |
C | HOH446 |
C | HOH483 |
C | HOH489 |
C | HOH492 |
C | HOH494 |
C | HOH517 |
C | HOH519 |
C | HOH525 |
C | HOH538 |
C | HOH561 |
C | HOH575 |
C | HOH641 |
site_id | AC3 |
Number of Residues | 37 |
Details | BINDING SITE FOR RESIDUE NAP D 300 |
Chain | Residue |
D | GLY10 |
D | GLY13 |
D | GLY14 |
D | LEU15 |
D | TYR34 |
D | SER35 |
D | ASN38 |
D | VAL60 |
D | ASP61 |
D | VAL62 |
D | ASN88 |
D | ALA89 |
D | GLY90 |
D | ILE91 |
D | THR111 |
D | SER139 |
D | TYR153 |
D | LYS157 |
D | PRO183 |
D | GLY184 |
D | LEU186 |
D | THR188 |
D | HOH410 |
D | HOH430 |
D | HOH480 |
D | HOH503 |
D | HOH506 |
D | HOH521 |
D | HOH535 |
D | HOH537 |
D | HOH542 |
D | HOH547 |
D | HOH574 |
D | HOH582 |
D | HOH625 |
D | HOH651 |
D | HOH670 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvngskgsvgQtnYAAAKAGMhGFTkSLA |
Chain | Residue | Details |
A | SER140-ALA168 |