Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS123 |
| A | GLU153 |
| B | ASP180 |
| C | GLY-2 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS39 |
| A | ASP77 |
| A | HOH657 |
| A | HOH658 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 303 |
| Chain | Residue |
| A | SO4304 |
| B | ASP181 |
| C | ASP181 |
| A | ASP181 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 304 |
| Chain | Residue |
| A | ASP180 |
| A | ASP181 |
| A | ZN303 |
| A | HOH403 |
| A | HOH416 |
| A | HOH652 |
| B | ASP180 |
| B | ASP181 |
| B | HOH541 |
| C | ASP180 |
| C | ASP181 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 305 |
| Chain | Residue |
| A | ARG86 |
| A | ASN96 |
| A | HOH639 |
| B | ARG86 |
| B | ASN96 |
| C | ARG86 |
| C | ASN96 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 306 |
| Chain | Residue |
| A | LYS6 |
| A | LYS8 |
| A | HOH659 |
| C | ARG115 |
| C | HOH456 |
| C | HOH630 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 307 |
| Chain | Residue |
| A | ARG183 |
| A | ASN184 |
| C | SER175 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 308 |
| Chain | Residue |
| A | ASP180 |
| A | SO4309 |
| A | HOH416 |
| C | HIS151 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 309 |
| Chain | Residue |
| A | GLY-2 |
| A | SER-1 |
| A | ASP180 |
| A | ZN308 |
| A | HOH404 |
| A | HOH416 |
| A | HOH430 |
| A | HOH595 |
| C | ASN2 |
| C | HIS151 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| A | HIS151 |
| A | HOH403 |
| B | ASP180 |
| B | SO4302 |
| site_id | BC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| A | ASN2 |
| A | HIS151 |
| A | HOH403 |
| A | HOH439 |
| B | ASP180 |
| B | ZN301 |
| B | HOH425 |
| B | HOH541 |
| C | GLY-2 |
| C | SER-1 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 303 |
| Chain | Residue |
| B | GLY-2 |
| B | HIS123 |
| B | GLU153 |
| C | ASP180 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 304 |
| Chain | Residue |
| B | HIS39 |
| B | ASP77 |
| B | HOH571 |
| B | HOH593 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 305 |
| Chain | Residue |
| B | LYS6 |
| B | LYS8 |
| B | ARG115 |
| B | HOH580 |
| B | HOH661 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 306 |
| Chain | Residue |
| A | SER175 |
| B | ASN184 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 307 |
| Chain | Residue |
| B | SER175 |
| B | HOH562 |
| C | ARG183 |
| C | ASN184 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 301 |
| Chain | Residue |
| A | HOH652 |
| B | HIS151 |
| C | ASP180 |
| C | SO4302 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 C 302 |
| Chain | Residue |
| C | HOH447 |
| A | HOH652 |
| B | SER-1 |
| B | ASN2 |
| B | HIS151 |
| B | HOH557 |
| B | HOH578 |
| C | ASP180 |
| C | ZN301 |
| C | HOH405 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 303 |
| Chain | Residue |
| A | GLY-2 |
| A | ASP180 |
| C | HIS123 |
| C | GLU153 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 304 |
| Chain | Residue |
| C | HIS39 |
| C | ASP77 |
| C | HOH515 |
| C | HOH670 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 305 |
| Chain | Residue |
| A | ARG115 |
| C | LYS6 |
| C | LYS8 |
| C | HOH666 |
Functional Information from PROSITE/UniProt
| site_id | PS00672 |
| Number of Residues | 15 |
| Details | V8_HIS Serine proteases, V8 family, histidine active site. TGFVVGknTIlTnkH |
| Chain | Residue | Details |
| A | THR25-HIS39 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"18448121","evidenceCode":"ECO:0000269"}]} |
