4K1C
VCX1 Calcium/Proton Exchanger
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000324 | cellular_component | fungal-type vacuole |
| A | 0000329 | cellular_component | fungal-type vacuole membrane |
| A | 0005773 | cellular_component | vacuole |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0006874 | biological_process | intracellular calcium ion homeostasis |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0015369 | molecular_function | calcium:proton antiporter activity |
| A | 0015386 | molecular_function | potassium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0000324 | cellular_component | fungal-type vacuole |
| B | 0000329 | cellular_component | fungal-type vacuole membrane |
| B | 0005773 | cellular_component | vacuole |
| B | 0005774 | cellular_component | vacuolar membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0006874 | biological_process | intracellular calcium ion homeostasis |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0015369 | molecular_function | calcium:proton antiporter activity |
| B | 0015386 | molecular_function | potassium:proton antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OLC A 501 |
| Chain | Residue |
| A | ILE52 |
| A | PHE56 |
| A | LEU58 |
| B | ILE143 |
| B | TYR147 |
| B | TYR216 |
| B | SER221 |
| B | TRP378 |
| B | VAL382 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE OLC A 502 |
| Chain | Residue |
| A | TYR147 |
| A | ALA386 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE OLC A 503 |
| Chain | Residue |
| A | GLU198 |
| A | ARG201 |
| A | TRP342 |
| A | ALA392 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE OLC A 504 |
| Chain | Residue |
| A | LEU51 |
| A | HIS55 |
| B | PHE144 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE OLC A 505 |
| Chain | Residue |
| A | LEU136 |
| A | ALA300 |
| A | HIS303 |
| A | VAL304 |
| A | MET311 |
| A | LYS312 |
| A | HOH610 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 506 |
| Chain | Residue |
| A | GLU302 |
| A | SER325 |
| A | HOH613 |
| A | HOH616 |
| A | HOH620 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 507 |
| Chain | Residue |
| A | GLN156 |
| A | ASP373 |
| A | GLU375 |
| A | HOH612 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A 508 |
| Chain | Residue |
| A | GLN228 |
| A | GLU231 |
| B | ASN148 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 509 |
| Chain | Residue |
| A | GLU83 |
| A | GLU230 |
| A | ASP234 |
| A | HOH608 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 510 |
| Chain | Residue |
| A | GLU83 |
| A | ASP87 |
| A | GLU230 |
| A | ASP234 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 511 |
| Chain | Residue |
| A | ASP373 |
| A | GLU375 |
| A | GLU380 |
| A | HOH614 |
| A | HOH627 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD A 512 |
| Chain | Residue |
| A | GLY117 |
| A | VAL119 |
| A | ARG120 |
| A | HOH609 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 513 |
| Chain | Residue |
| A | ARG201 |
| A | ASP345 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD A 514 |
| Chain | Residue |
| A | GLN57 |
| A | HIS60 |
| A | THR63 |
| A | HOH618 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IOD A 516 |
| Chain | Residue |
| A | LEU173 |
| A | LEU174 |
| A | PRO176 |
| A | ALA177 |
| A | LEU350 |
| A | PHE352 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 517 |
| Chain | Residue |
| A | HIS223 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 518 |
| Chain | Residue |
| A | ASP30 |
| A | HIS246 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 519 |
| Chain | Residue |
| A | LYS314 |
| A | MN521 |
| B | LYS312 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD A 520 |
| Chain | Residue |
| A | LYS312 |
| A | MN521 |
| B | VAL236 |
| B | THR239 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MN A 521 |
| Chain | Residue |
| A | IOD519 |
| A | IOD520 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE OLC B 501 |
| Chain | Residue |
| A | LEU62 |
| B | THR92 |
| B | LEU96 |
| B | LEU219 |
| B | GLY220 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 502 |
| Chain | Residue |
| B | GLN156 |
| B | ASP373 |
| B | GLU375 |
| B | HOH603 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 503 |
| Chain | Residue |
| B | GLU302 |
| B | SER325 |
| B | HOH609 |
| B | HOH613 |
| B | HOH630 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 504 |
| Chain | Residue |
| B | GLU83 |
| B | GLU230 |
| B | ASP234 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 505 |
| Chain | Residue |
| B | GLU83 |
| B | GLU230 |
| B | ASP234 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 506 |
| Chain | Residue |
| B | GLU375 |
| B | GLU380 |
| B | HOH614 |
| B | HOH615 |
| B | ASP373 |
| site_id | CC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 507 |
| Chain | Residue |
| B | GLN151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 182 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:16847258 |
| Chain | Residue | Details |
| A | MET1-ASP30 | |
| B | GLU227-SER252 | |
| B | MET311-LEU319 | |
| B | LEU372-GLU380 | |
| A | GLU83-ASN91 | |
| A | TYR147-GLN160 | |
| A | GLU227-SER252 | |
| A | MET311-LEU319 | |
| A | LEU372-GLU380 | |
| B | MET1-ASP30 | |
| B | GLU83-ASN91 | |
| B | TYR147-GLN160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 468 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU31-TRP53 | |
| A | THR349-ILE371 | |
| A | GLY381-TYR398 | |
| B | LEU31-TRP53 | |
| B | HIS60-THR82 | |
| B | THR92-LEU114 | |
| B | LEU127-GLY146 | |
| B | THR161-LEU183 | |
| B | SER204-PHE226 | |
| B | SER253-ILE275 | |
| B | PHE288-ALA310 | |
| A | HIS60-THR82 | |
| B | GLY320-TRP342 | |
| B | THR349-ILE371 | |
| B | GLY381-TYR398 | |
| A | THR92-LEU114 | |
| A | LEU127-GLY146 | |
| A | THR161-LEU183 | |
| A | SER204-PHE226 | |
| A | SER253-ILE275 | |
| A | PHE288-ALA310 | |
| A | GLY320-TRP342 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 126 |
| Details | TOPO_DOM: Vacuolar => ECO:0000269|PubMed:16847258 |
| Chain | Residue | Details |
| A | GLY54-SER59 | |
| B | ASP276-THR287 | |
| B | MET343-MET348 | |
| B | PRO399-LEU411 | |
| A | LYS115-MET126 | |
| A | PRO184-THR203 | |
| A | ASP276-THR287 | |
| A | MET343-MET348 | |
| A | PRO399-LEU411 | |
| B | GLY54-SER59 | |
| B | LYS115-MET126 | |
| B | PRO184-THR203 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377 |
| Chain | Residue | Details |
| A | SER13 | |
| B | SER13 |
