4K0R
Crystal structure of mouse Cryptochrome 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006111 | biological_process | regulation of gluconeogenesis |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0009416 | biological_process | response to light stimulus |
| A | 0009881 | molecular_function | photoreceptor activity |
| A | 0014823 | biological_process | response to activity |
| A | 0016922 | molecular_function | nuclear receptor binding |
| A | 0019900 | molecular_function | kinase binding |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0019902 | molecular_function | phosphatase binding |
| A | 0019915 | biological_process | lipid storage |
| A | 0031397 | biological_process | negative regulation of protein ubiquitination |
| A | 0031398 | biological_process | positive regulation of protein ubiquitination |
| A | 0032868 | biological_process | response to insulin |
| A | 0032922 | biological_process | circadian regulation of gene expression |
| A | 0033762 | biological_process | response to glucagon |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042752 | biological_process | regulation of circadian rhythm |
| A | 0042754 | biological_process | negative regulation of circadian rhythm |
| A | 0042770 | biological_process | signal transduction in response to DNA damage |
| A | 0042826 | molecular_function | histone deacetylase binding |
| A | 0043153 | biological_process | entrainment of circadian clock by photoperiod |
| A | 0045721 | biological_process | negative regulation of gluconeogenesis |
| A | 0045722 | biological_process | positive regulation of gluconeogenesis |
| A | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0048511 | biological_process | rhythmic process |
| A | 0070888 | molecular_function | E-box binding |
| A | 0071949 | molecular_function | FAD binding |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 2000001 | biological_process | regulation of DNA damage checkpoint |
| A | 2000323 | biological_process | negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway |
| A | 2000850 | biological_process | negative regulation of glucocorticoid secretion |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 99 |
| Details | Region: {"description":"Required for inhibition of CLOCK-BMAL1-mediated transcription","evidences":[{"source":"PubMed","id":"16478995","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"LIR 1","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 2","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 3","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 4","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 5","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 6","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Motif: {"description":"LIR 7","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 8","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 9","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 10","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 11","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23746849","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"19833968","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK","evidences":[{"source":"PubMed","id":"15298678","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23452855","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 5 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23452856","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
