4JZE

Structure of factor VIIA in complex with the inhibitor 2-{2-[(1-aminoisoquinolin-6-yl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1NK H 301

Chain	Residue
H	HIS57
H	GLY216
H	GLY219
H	CYS220
H	GLY226
H	GOL307
H	HOH423
H	HOH590
H	HOH632
H	THR151
H	ASP189
H	SER190
H	LYS192
H	GLY193
H	SER195
H	SER214
H	TRP215

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 302

Chain	Residue
H	GLU70
H	ASP72
H	GLU75
H	GLU80
H	HOH435
H	HOH512

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 303

Chain	Residue
H	ARG83
H	ARG84
H	HIS109
H	GLN110

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H 304

Chain	Residue
H	VAL35
H	ASN37
H	LYS60
H	ILE60
H	LYS60
H	ASN60
H	HOH648

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 305

Chain	Residue
H	SER170
H	ILE176
H	HIS224
H	PHE225
H	VAL227
H	HOH567

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H 306

Chain	Residue
H	ILE47
H	ASN48
H	GLN239
H	HOH513
H	HOH667
H	HOH689
L	HIS115

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL H 307

Chain	Residue
H	LEU41
H	HIS57
H	CYS58
H	1NK301
H	HOH502
H	HOH565

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 308

Chain	Residue
H	PHE59
H	TRP61
H	PRO96
H	ARG147
H	LEU251
H	HOH442
H	HOH535

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL H 309

Chain	Residue
H	GLU26
H	LEU137
H	HOH494
H	HOH634
L	ILE138

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
H	ASP189

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
H	ASN175

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