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4JYH

Crystal structure of RARbeta LBD in complex with selective agonist BMS948 [4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid]

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
A0048384biological_processretinoic acid receptor signaling pathway
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
B0048384biological_processretinoic acid receptor signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE JYH A 501
ChainResidue
APHE221
APHE295
ALEU224
AALA225
ACYS228
ALEU262
AILE266
AARG269
APHE279
ASER280

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE JYH B 501
ChainResidue
BPHE192
BLEU224
BALA225
BCYS228
BLEU262
BILE266
BARG269
BPHE279
BSER280
BLEU391
BHOH627

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE FLC G 701
ChainResidue
AGLU336
AGLU337
APRO338
ATHR339
GHIS630
GLYS631
GILE632
GARG635
GHOH803

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER641
GSER641

226707

PDB entries from 2024-10-30

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