4JY3
Crystal structure of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, 5-pyridoxic acid bound form
Replaces: 3ALIReplaces: 4H28Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0047081 | molecular_function | 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity |
| A | 0071949 | molecular_function | FAD binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0047081 | molecular_function | 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity |
| B | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD A 401 |
| Chain | Residue |
| A | GLY18 |
| A | TYR54 |
| A | ARG106 |
| A | SER128 |
| A | GLU129 |
| A | ALA130 |
| A | ALA155 |
| A | ASP156 |
| A | GLY157 |
| A | LEU179 |
| A | ARG181 |
| A | GLY19 |
| A | GLY287 |
| A | ASP288 |
| A | ALA298 |
| A | GLY300 |
| A | ALA301 |
| A | GLY302 |
| A | 5PR403 |
| A | HOH501 |
| A | HOH502 |
| A | HOH503 |
| A | GLY20 |
| A | HOH504 |
| A | HOH542 |
| A | HOH584 |
| A | HOH660 |
| A | HOH687 |
| A | HOH702 |
| A | HOH735 |
| A | HOH787 |
| A | HOH821 |
| A | PHE21 |
| A | ALA22 |
| A | HIS40 |
| A | GLU41 |
| A | LYS42 |
| A | ILE53 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME A 402 |
| Chain | Residue |
| A | TRP173 |
| A | TYR270 |
| A | CYS294 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 5PR A 403 |
| Chain | Residue |
| A | TYR54 |
| A | LEU179 |
| A | ARG211 |
| A | LEU213 |
| A | TYR223 |
| A | MET227 |
| A | TYR270 |
| A | PRO295 |
| A | ALA296 |
| A | ALA298 |
| A | LEU352 |
| A | FAD401 |
| A | HOH606 |
| A | HOH608 |
| A | HOH628 |
| A | HOH631 |
| A | HOH702 |
| A | HOH959 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | LEU73 |
| A | GLN74 |
| A | GLY75 |
| A | SER76 |
| A | ASN97 |
| A | ARG102 |
| A | PRO378 |
| A | HOH561 |
| A | HOH566 |
| A | HOH720 |
| A | HOH899 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | THR95 |
| A | PHE96 |
| A | ASN97 |
| A | HOH520 |
| A | HOH581 |
| A | HOH705 |
| A | HOH712 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 406 |
| Chain | Residue |
| A | LYS42 |
| A | ASN127 |
| A | GLU129 |
| A | GLN142 |
| A | THR143 |
| A | HOH558 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 407 |
| Chain | Residue |
| A | GLU364 |
| A | ARG367 |
| A | TYR375 |
| site_id | AC8 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD B 401 |
| Chain | Residue |
| B | ALA130 |
| B | ALA155 |
| B | ASP156 |
| B | GLY157 |
| B | LEU179 |
| B | ARG181 |
| B | GLY287 |
| B | ASP288 |
| B | ALA298 |
| B | GLY300 |
| B | ALA301 |
| B | GLY302 |
| B | 5PR403 |
| B | HOH502 |
| B | HOH503 |
| B | HOH505 |
| B | HOH520 |
| B | HOH614 |
| B | HOH657 |
| B | HOH701 |
| B | HOH718 |
| B | HOH733 |
| B | HOH802 |
| B | HOH859 |
| B | GLY18 |
| B | GLY19 |
| B | GLY20 |
| B | PHE21 |
| B | ALA22 |
| B | HIS40 |
| B | GLU41 |
| B | LYS42 |
| B | ILE53 |
| B | TYR54 |
| B | ARG106 |
| B | SER128 |
| B | GLU129 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME B 402 |
| Chain | Residue |
| B | TRP173 |
| B | TYR270 |
| B | CYS294 |
| B | ALA347 |
| B | EDO408 |
| site_id | BC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 5PR B 403 |
| Chain | Residue |
| B | TYR54 |
| B | LEU179 |
| B | ARG211 |
| B | LEU213 |
| B | TYR223 |
| B | PRO295 |
| B | ALA296 |
| B | ALA298 |
| B | LEU352 |
| B | FAD401 |
| B | HOH552 |
| B | HOH582 |
| B | HOH664 |
| B | HOH735 |
| B | HOH859 |
| B | HOH965 |
| site_id | BC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GOL B 404 |
| Chain | Residue |
| B | LEU73 |
| B | GLN74 |
| B | GLY75 |
| B | SER76 |
| B | ASN97 |
| B | ARG102 |
| B | PRO378 |
| B | HOH596 |
| B | HOH612 |
| B | HOH744 |
| B | HOH825 |
| B | HOH947 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 405 |
| Chain | Residue |
| B | THR279 |
| B | GLY281 |
| B | VAL326 |
| B | HOH514 |
| B | HOH750 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 406 |
| Chain | Residue |
| B | LYS42 |
| B | ASN127 |
| B | GLU129 |
| B | GLN142 |
| B | THR143 |
| B | HOH611 |
| B | HOH850 |
| B | HOH852 |
| B | HOH853 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 407 |
| Chain | Residue |
| B | ARG367 |
| B | TYR375 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 408 |
| Chain | Residue |
| B | TRP173 |
| B | CYS294 |
| B | GLY344 |
| B | ALA348 |
| B | BME402 |
| B | HOH698 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19317437","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27568368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ALJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ALL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ALM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HXI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27568368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JY3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19317437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19317437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GMC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
