4JXC

X-ray snapshots of possible intermediates in the time course of synthesis and degradation of protein-bound Fe4S4 clusters

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0042364	biological_process	water-soluble vitamin biosynthetic process
A	0044272	biological_process	sulfur compound biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SF4 A 401

Chain	Residue
A	CYS63
A	CYS67
A	CYS70
A	GLY109
A	SAM402

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SAM A 402

Chain	Residue
A	ARG159
A	GLU161
A	ARG180
A	MET199
A	PRO229
A	ILE231
A	TYR303
A	LEU305
A	TYR306
A	SF4401
A	HOH511
A	HOH517
A	HOH519
A	HOH528
A	HOH567
A	TYR69
A	SER108
A	SER136
A	GLY138

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 1N7 A 403

Chain	Residue
A	GLN98
A	PHE99
A	GLY100
A	GLU280
A	ARG284
A	MET324
A	LEU330
A	1N7406
A	1N7407
A	IPA412
A	HOH508
A	HOH544
A	HOH594
A	HOH606
A	HOH812
A	HOH813

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1N7 A 404

Chain	Residue
A	LYS37
A	ASP40
A	LYS170
A	ARG284
A	SER297
A	LYS315
A	ASP316
A	THR317
A	HOH598
A	HOH648
A	HOH676
A	HOH695
A	HOH701
A	HOH821

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1N7 A 405

Chain	Residue
A	ARG29
A	GLU33
A	THR247
A	LEU250
A	1N7406
A	HOH593
A	HOH597
A	HOH603
A	HOH798

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1N7 A 406

Chain	Residue
A	ARG29
A	LYS315
A	THR317
A	ALA318
A	1N7403
A	1N7405
A	1N7407
A	HOH632
A	HOH728
A	HOH828

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1N7 A 407

Chain	Residue
A	LYS128
A	PRO321
A	MET324
A	LYS325
A	GLU328
A	1N7403
A	1N7406
A	HOH530
A	HOH744
A	HOH799
A	HOH805

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 408

Chain	Residue
A	VAL47
A	HIS52
A	ASP262
A	ASN264
A	GLY340
A	ARG341
A	LYS342
A	HOH550

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES A 409

Chain	Residue
A	HOH622
A	ARG279
A	CYS311
A	CYS319
A	CYS322
A	VAL323
A	H2S410
A	H2S411

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE H2S A 410

Chain	Residue
A	CYS311
A	CYS319
A	FES409

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE H2S A 411

Chain	Residue
A	ARG279
A	CYS322
A	MET326
A	FES409

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IPA A 412

Chain	Residue
A	LYS102
A	LYS325
A	1N7403
A	HOH570
A	HOH779

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 413

Chain	Residue
A	ARG54
A	THR134
A	ARG155
A	MET224

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 414

Chain	Residue
A	ARG159
A	THR269
A	ALA270
A	TYR306
A	HOH822

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 415

Chain	Residue
A	ASP337
A	TRP338
A	GLY339
A	GLY340
A	LYS342
A	HOH536
A	HOH720

---

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	18
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. VMKMIELLGRKpgrdwgG

Chain	Residue	Details
A	VAL323-GLY340

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR004762-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16137685","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18400755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706452","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR004762-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16137685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JYE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JYE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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