4JVR
Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| E | 0005634 | cellular_component | nucleus |
| E | 0043066 | biological_process | negative regulation of apoptotic process |
| E | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1MT A 201 |
| Chain | Residue |
| A | LEU54 |
| A | HOH342 |
| A | LEU57 |
| A | GLY58 |
| A | MET62 |
| A | TYR67 |
| A | HIS96 |
| A | ILE99 |
| A | TYR100 |
| A | HOH321 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1MT C 201 |
| Chain | Residue |
| C | LEU54 |
| C | LEU57 |
| C | ILE61 |
| C | MET62 |
| C | TYR67 |
| C | VAL93 |
| C | HIS96 |
| C | ILE99 |
| C | TYR100 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1MT E 201 |
| Chain | Residue |
| E | LEU54 |
| E | GLY58 |
| E | ILE61 |
| E | MET62 |
| E | PHE86 |
| E | HIS96 |
| E | ILE99 |
| E | TYR100 |
| E | HOH302 |
| E | HOH379 |
| E | HOH380 |