4JVR
Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0051726 | biological_process | regulation of cell cycle |
C | 0005634 | cellular_component | nucleus |
C | 0043066 | biological_process | negative regulation of apoptotic process |
C | 0051726 | biological_process | regulation of cell cycle |
E | 0005634 | cellular_component | nucleus |
E | 0043066 | biological_process | negative regulation of apoptotic process |
E | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 1MT A 201 |
Chain | Residue |
A | LEU54 |
A | HOH342 |
A | LEU57 |
A | GLY58 |
A | MET62 |
A | TYR67 |
A | HIS96 |
A | ILE99 |
A | TYR100 |
A | HOH321 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE 1MT C 201 |
Chain | Residue |
C | LEU54 |
C | LEU57 |
C | ILE61 |
C | MET62 |
C | TYR67 |
C | VAL93 |
C | HIS96 |
C | ILE99 |
C | TYR100 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 1MT E 201 |
Chain | Residue |
E | LEU54 |
E | GLY58 |
E | ILE61 |
E | MET62 |
E | PHE86 |
E | HIS96 |
E | ILE99 |
E | TYR100 |
E | HOH302 |
E | HOH379 |
E | HOH380 |