4JVL
Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and estradiol (E2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004062 | molecular_function | aryl sulfotransferase activity |
| A | 0004304 | molecular_function | estrone sulfotransferase activity |
| A | 0005496 | molecular_function | steroid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006711 | biological_process | estrogen catabolic process |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008210 | biological_process | estrogen metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0045600 | biological_process | positive regulation of fat cell differentiation |
| A | 0047894 | molecular_function | flavonol 3-sulfotransferase activity |
| A | 0050294 | molecular_function | steroid sulfotransferase activity |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0051923 | biological_process | sulfation |
| B | 0004062 | molecular_function | aryl sulfotransferase activity |
| B | 0004304 | molecular_function | estrone sulfotransferase activity |
| B | 0005496 | molecular_function | steroid binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006711 | biological_process | estrogen catabolic process |
| B | 0006790 | biological_process | sulfur compound metabolic process |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0008210 | biological_process | estrogen metabolic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0045600 | biological_process | positive regulation of fat cell differentiation |
| B | 0047894 | molecular_function | flavonol 3-sulfotransferase activity |
| B | 0050294 | molecular_function | steroid sulfotransferase activity |
| B | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P A 701 |
| Chain | Residue |
| A | LYS47 |
| A | THR226 |
| A | SER227 |
| A | PHE228 |
| A | MET231 |
| A | PHE254 |
| A | MET255 |
| A | ARG256 |
| A | LYS257 |
| A | GLY258 |
| A | HOH812 |
| A | SER48 |
| A | HOH816 |
| A | HOH820 |
| A | HOH830 |
| A | HOH840 |
| A | GLY49 |
| A | THR50 |
| A | THR51 |
| A | TRP52 |
| A | ARG129 |
| A | SER137 |
| A | TYR192 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EST A 702 |
| Chain | Residue |
| A | TYR20 |
| A | PHE80 |
| A | LYS105 |
| A | HIS107 |
| A | PHE141 |
| A | ALA146 |
| A | HOH812 |
| A | HOH900 |
| A | HOH957 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 703 |
| Chain | Residue |
| A | GLY182 |
| A | SER184 |
| A | VAL187 |
| A | HOH1088 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 704 |
| Chain | Residue |
| A | LYS257 |
| A | ASN265 |
| A | HOH987 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 705 |
| Chain | Residue |
| A | GLU31 |
| A | GLU111 |
| A | LEU112 |
| A | LEU113 |
| A | HOH846 |
| A | HOH849 |
| B | HOH593 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 706 |
| Chain | Residue |
| A | TYR26 |
| A | ASN29 |
| A | ARG84 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P B 301 |
| Chain | Residue |
| B | LYS47 |
| B | SER48 |
| B | GLY49 |
| B | THR50 |
| B | THR51 |
| B | TRP52 |
| B | ARG129 |
| B | SER137 |
| B | TYR192 |
| B | THR226 |
| B | SER227 |
| B | PHE228 |
| B | MET231 |
| B | PHE254 |
| B | MET255 |
| B | ARG256 |
| B | LYS257 |
| B | GLY258 |
| B | HOH405 |
| B | HOH414 |
| B | HOH417 |
| B | HOH419 |
| B | HOH463 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EST B 302 |
| Chain | Residue |
| B | TYR20 |
| B | PHE80 |
| B | LYS105 |
| B | HIS107 |
| B | ALA146 |
| B | HOH417 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 303 |
| Chain | Residue |
| B | ASP194 |
| B | LYS201 |
| B | GLU202 |
| B | LYS205 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 304 |
| Chain | Residue |
| B | GLY182 |
| B | SER184 |
| B | VAL187 |
| B | HOH418 |
| B | HOH439 |
| B | HOH494 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA B 305 |
| Chain | Residue |
| B | TYR8 |
| B | PHE11 |
| B | GLU12 |
| B | HOH577 |
| B | HOH580 |
| B | HOH636 |
| B | HOH640 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11006110","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P49891","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11884392","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 154 |
| Chain | Residue | Details |
| A | LYS47 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS107 | hydrogen bond acceptor, proton acceptor, proton donor, proton relay |
| A | SER137 | hydrogen bond acceptor, steric role |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 154 |
| Chain | Residue | Details |
| B | LYS47 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS107 | hydrogen bond acceptor, proton acceptor, proton donor, proton relay |
| B | SER137 | hydrogen bond acceptor, steric role |
