4JV9

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 1MO A 201

Chain	Residue
A	LEU54
A	ILE99
A	THR101
A	TYR104
A	HOH308
A	PHE55
A	LEU57
A	GLY58
A	GLN59
A	ILE61
A	MET62
A	GLN72
A	ARG97

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	LYS31
A	PRO32
A	LEU33
A	HOH321
A	HOH330

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	LYS51
A	LYS94
A	HIS96
A	ARG97
A	HOH304

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