4JU7

Crystal structure of hcv ns5b polymerase in complex with compound 24

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1O6 A 601

Chain	Residue
A	LEU419
A	ARG422
A	HIS475
A	SER476
A	TYR477
A	ILE482
A	ALA486
A	LEU497
A	TRP528

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 602

Chain	Residue
A	ASP220
A	THR221
A	HOH779
A	HOH793

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG B 601

Chain	Residue
B	ASP220

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	236
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P26663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---