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4JU4

Crystal structure of hcv ns5b polymerase in complex with compound 22

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 1O3 A 601
ChainResidue
ALEU419
ALEU474
AHIS475
ASER476
ATYR477
AILE482
ALEU497
ATRP528
AHOH732

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 602
ChainResidue
AASP220
ATHR221
AHOH835
AHOH846

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 1O3 B 601
ChainResidue
BLEU419
BARG422
BMET423
BLEU474
BHIS475
BSER476
BTYR477
BILE482
BARG501
BTRP528

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 602
ChainResidue
BASP220
BTHR221
BHOH743
BHOH762
BHOH789

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-11-06

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