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4JTZ

Crystal structure of hcv ns5b polymerase in complex with compound 4

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 3001
ChainResidue
ASER96
AALA97
AARG168

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 1NW A 3002
ChainResidue
ATYR477
AILE482
AVAL485
AALA486
AARG490
APRO496
ALEU497
ATRP528
AHOH3221
ALEU419
AARG422
AMET423
ALEU474
AHIS475
ASER476

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 3003
ChainResidue
AGLN194
APHE551
AHOH3270

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 3004
ChainResidue
AASP220
ATHR221
AHOH3130

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 601
ChainResidue
BSER96
BALA97
BPHE162

site_idAC6
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 1NW B 602
ChainResidue
ALYS209
BLEU419
BARG422
BMET423
BLEU474
BHIS475
BSER476
BTYR477
BILE482
BALA486
BLEU489
BARG490
BVAL494
BPRO496
BLEU497
BTRP528

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 603
ChainResidue
BGLN194
BGLN199
BPHE551
BHOH1100

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG B 604
ChainResidue
BASP220
BHOH1160

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-11-20

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