4JSP
structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0016301 | molecular_function | kinase activity |
A | 0044877 | molecular_function | protein-containing complex binding |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0016301 | molecular_function | kinase activity |
B | 0044877 | molecular_function | protein-containing complex binding |
C | 0005515 | molecular_function | protein binding |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005737 | cellular_component | cytoplasm |
C | 0005764 | cellular_component | lysosome |
C | 0005765 | cellular_component | lysosomal membrane |
C | 0005829 | cellular_component | cytosol |
C | 0006974 | biological_process | DNA damage response |
C | 0007010 | biological_process | cytoskeleton organization |
C | 0010507 | biological_process | negative regulation of autophagy |
C | 0016020 | cellular_component | membrane |
C | 0030307 | biological_process | positive regulation of cell growth |
C | 0030838 | biological_process | positive regulation of actin filament polymerization |
C | 0031669 | biological_process | cellular response to nutrient levels |
C | 0031929 | biological_process | TOR signaling |
C | 0031931 | cellular_component | TORC1 complex |
C | 0031932 | cellular_component | TORC2 complex |
C | 0032008 | biological_process | positive regulation of TOR signaling |
C | 0032956 | biological_process | regulation of actin cytoskeleton organization |
C | 0038202 | biological_process | TORC1 signaling |
C | 0043066 | biological_process | negative regulation of apoptotic process |
C | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
C | 0045821 | biological_process | positive regulation of glycolytic process |
C | 0046889 | biological_process | positive regulation of lipid biosynthetic process |
C | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
C | 0071456 | biological_process | cellular response to hypoxia |
C | 0071470 | biological_process | cellular response to osmotic stress |
C | 1905857 | biological_process | positive regulation of pentose-phosphate shunt |
D | 0005515 | molecular_function | protein binding |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0005764 | cellular_component | lysosome |
D | 0005765 | cellular_component | lysosomal membrane |
D | 0005829 | cellular_component | cytosol |
D | 0006974 | biological_process | DNA damage response |
D | 0007010 | biological_process | cytoskeleton organization |
D | 0010507 | biological_process | negative regulation of autophagy |
D | 0016020 | cellular_component | membrane |
D | 0030307 | biological_process | positive regulation of cell growth |
D | 0030838 | biological_process | positive regulation of actin filament polymerization |
D | 0031669 | biological_process | cellular response to nutrient levels |
D | 0031929 | biological_process | TOR signaling |
D | 0031931 | cellular_component | TORC1 complex |
D | 0031932 | cellular_component | TORC2 complex |
D | 0032008 | biological_process | positive regulation of TOR signaling |
D | 0032956 | biological_process | regulation of actin cytoskeleton organization |
D | 0038202 | biological_process | TORC1 signaling |
D | 0043066 | biological_process | negative regulation of apoptotic process |
D | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
D | 0045821 | biological_process | positive regulation of glycolytic process |
D | 0046889 | biological_process | positive regulation of lipid biosynthetic process |
D | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
D | 0071456 | biological_process | cellular response to hypoxia |
D | 0071470 | biological_process | cellular response to osmotic stress |
D | 1905857 | biological_process | positive regulation of pentose-phosphate shunt |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE AGS B 3000 |
Chain | Residue |
B | SER2165 |
B | VAL2240 |
B | MG3001 |
B | MG3002 |
B | GLN2167 |
B | LEU2185 |
B | LYS2187 |
B | GLU2190 |
B | TYR2225 |
B | ILE2237 |
B | GLY2238 |
B | TRP2239 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 3001 |
Chain | Residue |
B | ASN2343 |
B | ASP2357 |
B | AGS3000 |
B | MG3002 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 3002 |
Chain | Residue |
B | GLU2190 |
B | ASP2357 |
B | AGS3000 |
B | MG3001 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE AGS A 3000 |
Chain | Residue |
A | SER2165 |
A | GLN2167 |
A | LEU2185 |
A | LYS2187 |
A | GLU2190 |
A | GLY2238 |
A | TRP2239 |
A | VAL2240 |
A | MET2345 |
A | MG3001 |
A | MG3002 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG A 3001 |
Chain | Residue |
A | ASN2343 |
A | AGS3000 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG A 3002 |
Chain | Residue |
A | GLU2190 |
A | ASP2357 |
A | AGS3000 |
Functional Information from PROSITE/UniProt
site_id | PS00678 |
Number of Residues | 15 |
Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL |
Chain | Residue | Details |
D | MET100-LEU114 |
site_id | PS00915 |
Number of Residues | 15 |
Details | PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ |
Chain | Residue | Details |
B | LEU2186-GLN2200 |
site_id | PS00916 |
Number of Residues | 21 |
Details | PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN |
Chain | Residue | Details |
B | SER2323-ASN2343 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
D | MET1 | |
B | MET2345 | |
B | ILE2356 | |
A | SER2165 | |
A | GLN2167 | |
A | LEU2185 | |
A | GLU2190 | |
A | TYR2225 | |
A | GLY2238 | |
A | TRP2239 | |
A | VAL2240 | |
C | MET1 | |
A | THR2245 | |
A | MET2345 | |
A | ILE2356 | |
B | LEU2185 | |
B | GLU2190 | |
B | TYR2225 | |
B | GLY2238 | |
B | TRP2239 | |
B | VAL2240 | |
B | THR2245 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:34741373 |
Chain | Residue | Details |
D | THR51 | |
C | THR51 | |
B | ASP2357 | |
A | LYS2187 | |
A | ASN2343 | |
A | ASP2357 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:29150432 |
Chain | Residue | Details |
B | SER2159 | |
A | SER2159 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:21576368 |
Chain | Residue | Details |
B | THR2164 | |
A | THR2164 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:24247430 |
Chain | Residue | Details |
B | THR2173 | |
A | THR2173 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by RPS6KB1 => ECO:0000269|PubMed:15905173 |
Chain | Residue | Details |
B | THR2446 | |
A | THR2446 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by RPS6KB1 => ECO:0000269|PubMed:15905173, ECO:0000269|PubMed:19145465, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | SER2448 | |
A | SER2448 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
B | SER2478 | |
A | SER2478 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:21576368, ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
B | SER2481 | |
A | SER2481 |