4JRO

Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (FabG)from Listeria monocytogenes in complex with NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008610	biological_process	lipid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008610	biological_process	lipid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0051287	molecular_function	NAD binding
C	0000166	molecular_function	nucleotide binding
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008610	biological_process	lipid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0051287	molecular_function	NAD binding
D	0000166	molecular_function	nucleotide binding
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0008610	biological_process	lipid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0046394	biological_process	carboxylic acid biosynthetic process
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAP B 301

Chain	Residue
B	GLY12
B	SER39
B	ALA62
B	ASN63
B	VAL64
B	ASN90
B	ALA91
B	GLY92
B	ILE113
B	ALA141
B	SER142
B	SER14
B	TYR155
B	LYS159
B	PRO185
B	GLY186
B	ILE188
B	HOH414
B	ARG15
B	GLY16
B	ILE17
B	ASN35
B	TYR36
B	ASN37
B	GLY38

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site_id	AC2
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAP C 301

Chain	Residue
C	GLY12
C	SER14
C	ARG15
C	GLY16
C	ILE17
C	ASN35
C	TYR36
C	ASN37
C	GLY38
C	SER39
C	ALA62
C	ASN63
C	VAL64
C	ASN90
C	ALA91
C	GLY92
C	ILE93
C	ILE113
C	MET140
C	ALA141
C	SER142
C	TYR155
C	LYS159
C	PRO185
C	GLY186
C	ILE188
C	THR190
C	HOH455
C	HOH518
C	HOH535

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site_id	AC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAP D 301

Chain	Residue
D	GLY12
D	SER14
D	ARG15
D	GLY16
D	ILE17
D	ASN35
D	TYR36
D	ASN37
D	GLY38
D	SER39
D	ALA62
D	ASN63
D	VAL64
D	ASN90
D	ALA91
D	GLY92
D	ILE113
D	ALA141
D	SER142
D	TYR155
D	LYS159
D	PRO185
D	GLY186
D	ILE188
D	HOH509
D	HOH542
D	HOH544
D	HOH547

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Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvglignagQanYVASKAGViGLTkTTA

Chain	Residue	Details
A	SER142-ALA170

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