4JR7
Crystal structure of scCK2 alpha in complex with GMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000028 | biological_process | ribosomal small subunit assembly |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
| A | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007535 | biological_process | donor selection |
| A | 0016310 | biological_process | phosphorylation |
| A | 0030490 | biological_process | maturation of SSU-rRNA |
| A | 0032040 | cellular_component | small-subunit processome |
| A | 0032545 | cellular_component | CURI complex |
| A | 0034456 | cellular_component | UTP-C complex |
| A | 0042790 | biological_process | nucleolar large rRNA transcription by RNA polymerase I |
| A | 0044024 | molecular_function | histone H2AS1 kinase activity |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0060962 | biological_process | regulation of ribosomal protein gene transcription by RNA polymerase II |
| A | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GNP A 401 |
| Chain | Residue |
| A | VAL46 |
| A | LYS197 |
| A | HIS199 |
| A | ASN200 |
| A | MET202 |
| A | ILE213 |
| A | ASP214 |
| A | MG402 |
| A | HOH501 |
| A | HOH539 |
| A | HOH542 |
| A | GLY47 |
| A | HOH655 |
| A | ARG48 |
| A | SER52 |
| A | VAL54 |
| A | VAL67 |
| A | LYS69 |
| A | VAL155 |
| A | ASP195 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ASN200 |
| A | ASP214 |
| A | GNP401 |
| A | HOH501 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFqGvkldskvk..........IVIK |
| Chain | Residue | Details |
| A | VAL46-LYS69 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE191-ILE203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | VAL46 | |
| A | LYS69 |
