4JQY

Human procaspase-3, crystal form 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HskrsSfvCvLLSHG

Chain	Residue	Details
A	HIS108-GLY122

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P29466

Chain	Residue	Details
A	HIS121
A	ALA163
B	HIS121
B	ALA163

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine; in inhibited form => ECO:0000269|PubMed:10213689

Chain	Residue	Details
A	ALA163
B	ALA163

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631

Chain	Residue	Details
A	ARG207
B	ARG207

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 815

Chain	Residue	Details
A	THR62	electrostatic stabiliser
A	SER63	electrostatic stabiliser
A	HIS121	electrostatic stabiliser, proton acceptor, proton donor
A	GLY122	electrostatic stabiliser
A	ALA163	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	5
Details	M-CSA 815

Chain	Residue	Details
B	THR62	electrostatic stabiliser
B	SER63	electrostatic stabiliser
B	HIS121	electrostatic stabiliser, proton acceptor, proton donor
B	GLY122	electrostatic stabiliser
B	ALA163	electrostatic stabiliser

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