4JQO

Crystal structure of anabolic ornithine carbamoyltransferase from Vibrio vulnificus in complex with citrulline and inorganic phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	L-arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	L-arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 401

Chain	Residue
A	SER57
A	THR58
A	ARG59
A	THR60
A	ARG108
A	CIR402
B	GLN84

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CIR A 402

Chain	Residue
A	HIS135
A	GLN138
A	ASN169
A	ASP233
A	SER237
A	MET238
A	CYS275
A	LEU276
A	ARG320
A	PO4401
A	HOH598
B	HOH619
A	THR60
A	ARG108

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 403

Chain	Residue
A	LEU13
A	PHE134
A	PRO136
A	SER173
A	HOH510

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 404

Chain	Residue
A	LEU262
A	ASN267
A	PRO268
A	HOH654

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 405

Chain	Residue
A	GLY295
A	HOH569

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 406

Chain	Residue
A	ARG167
A	ALA192

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 401

Chain	Residue
B	SER57
B	THR58
B	ARG59
B	THR60
B	ARG108
B	CIR402
C	GLN84

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CIR B 402

Chain	Residue
B	THR60
B	ARG108
B	HIS135
B	GLN138
B	ASN169
B	ASP233
B	SER237
B	MET238
B	CYS275
B	LEU276
B	ARG320
B	PO4401
B	HOH523
C	HOH515

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 403

Chain	Residue
B	LEU13
B	PHE134
B	PRO136
B	SER173
B	HOH522

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG B 404

Chain	Residue
B	LEU262
B	ASN267
B	PRO268
B	HIS310

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG B 405

Chain	Residue
A	GLU307
B	HOH622

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 401

Chain	Residue
A	GLN84
C	SER57
C	THR58
C	ARG59
C	THR60
C	ARG108
C	CIR402

---

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CIR C 402

Chain	Residue
C	THR60
C	ARG108
C	LEU130
C	HIS135
C	GLN138
C	ASN169
C	ASP233
C	SER237
C	MET238
C	CYS275
C	LEU276
C	ARG320
C	PO4401
C	HOH520
C	HOH537

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 403

Chain	Residue
C	LEU13
C	SER173

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG C 404

Chain	Residue
C	LEU262
C	LYS263
C	ASN267
C	HIS310

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG C 405

Chain	Residue
C	LYS213
C	THR215

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FeKaSTRT

Chain	Residue	Details
A	PHE53-THR60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2012","submissionDatabase":"PDB data bank","title":"Structural studies of ornithine carbamoyltransferase from various pathogens.","authors":["Shabalin I.G.","Winsor J.","Grimshaw S.","Osinski T.","Chordia M.D.","Anderson W.F.","Minor W."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2013","submissionDatabase":"PDB data bank","title":"Crystal structures and kinetic properties of anabolic ornithine carbamoyltransferase from human pathogens Vibrio vulnificus and Bacillus anthracis.","authors":["Shabalin I.G.","Winsor J.","Grimshaw S.","Minor W."]}},{"source":"PDB","id":"4H31","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JFR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2012","submissionDatabase":"PDB data bank","title":"Structural studies of ornithine carbamoyltransferase from various pathogens.","authors":["Shabalin I.G.","Winsor J.","Grimshaw S.","Osinski T.","Chordia M.D.","Anderson W.F.","Minor W."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2013","submissionDatabase":"PDB data bank","title":"Crystal structures and kinetic properties of anabolic ornithine carbamoyltransferase from human pathogens Vibrio vulnificus and Bacillus anthracis.","authors":["Shabalin I.G.","Winsor J.","Grimshaw S.","Minor W."]}},{"source":"PDB","id":"4H31","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2012","submissionDatabase":"PDB data bank","title":"Structural studies of ornithine carbamoyltransferase from various pathogens.","authors":["Shabalin I.G.","Winsor J.","Grimshaw S.","Osinski T.","Chordia M.D.","Anderson W.F.","Minor W."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2013","submissionDatabase":"PDB data bank","title":"Crystal structures and kinetic properties of anabolic ornithine carbamoyltransferase from human pathogens Vibrio vulnificus and Bacillus anthracis.","authors":["Shabalin I.G.","Winsor J.","Grimshaw S.","Minor W."]}},{"source":"PDB","id":"4H31","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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