Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4JQI

Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0001664molecular_functionG protein-coupled receptor binding
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0003713molecular_functiontranscription coactivator activity
A0004402molecular_functionhistone acetyltransferase activity
A0005096molecular_functionGTPase activator activity
A0005102molecular_functionsignaling receptor binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006511biological_processubiquitin-dependent protein catabolic process
A0006897biological_processendocytosis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007601biological_processvisual perception
A0007602biological_processphototransduction
A0008277biological_processregulation of G protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009968biological_processnegative regulation of signal transduction
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016567biological_processprotein ubiquitination
A0019899molecular_functionenzyme binding
A0030276molecular_functionclathrin binding
A0030331molecular_functionnuclear estrogen receptor binding
A0031143cellular_componentpseudopodium
A0031397biological_processnegative regulation of protein ubiquitination
A0031398biological_processpositive regulation of protein ubiquitination
A0031410cellular_componentcytoplasmic vesicle
A0031434molecular_functionmitogen-activated protein kinase kinase binding
A0031625molecular_functionubiquitin protein ligase binding
A0031691molecular_functionalpha-1A adrenergic receptor binding
A0031692molecular_functionalpha-1B adrenergic receptor binding
A0031701molecular_functionangiotensin receptor binding
A0031762molecular_functionfollicle-stimulating hormone receptor binding
A0031896molecular_functionV2 vasopressin receptor binding
A0032715biological_processnegative regulation of interleukin-6 production
A0032717biological_processnegative regulation of interleukin-8 production
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0035025biological_processpositive regulation of Rho protein signal transduction
A0035612molecular_functionAP-2 adaptor complex binding
A0035615molecular_functionclathrin adaptor activity
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042699biological_processfollicle-stimulating hormone signaling pathway
A0042981biological_processregulation of apoptotic process
A0042995cellular_componentcell projection
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043149biological_processstress fiber assembly
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043197cellular_componentdendritic spine
A0043278biological_processresponse to morphine
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0045211cellular_componentpostsynaptic membrane
A0045309molecular_functionprotein phosphorylated amino acid binding
A0045746biological_processnegative regulation of Notch signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050975biological_processsensory perception of touch
A0051219molecular_functionphosphoprotein binding
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A1990763molecular_functionarrestin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 401
ChainResidue
ATHR304
ALEU305
ALEU306

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO A 402
ChainResidue
HPHE105
HEDO304
HHOH427
AHIS210
AHIS353
APRO354
AHOH554
HSER34
HARG103

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL H 301
ChainResidue
HTYR63
HLYS68

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO H 302
ChainResidue
HTYR63
HLYS68
HGLY69
HPHE71
HTHR72

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO H 303
ChainResidue
AASP297
HTYR58
HGLN104
HTRP106

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO H 304
ChainResidue
AEDO402
HASN31
HSER34

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO L 301
ChainResidue
LLYS93
LTYR94
LVAL95
LPRO303

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO L 302
ChainResidue
HTYR107
LALA33
LSER51
LTYR92

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PRO L 303
ChainResidue
HTYR107
LTYR92
LEDO301

site_idBC1
Number of Residues34
DetailsBINDING SITE FOR CHAIN V OF VASOPRESSIN V2 RECEPTOR PHOSPHOPEPTIDE
ChainResidue
ATHR6
AARG7
AVAL8
ALYS10
ALYS11
AALA12
ATYR21
AARG25
AARG62
ATYR63
AARG65
ALEU71
AGLY72
ALEU73
ATHR74
APHE75
AARG76
ALYS77
AARG103
ALYS107
ATHR136
ALYS138
AARG161
AARG165
ALEU166
ALYS294
AHOH506
AHOH518
LSER31
LARG67
VHOH401
VHOH402
VHOH403
VHOH404

Functional Information from PROSITE/UniProt
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR193-HIS199
HTYR204-HIS210

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALYS250
AMET255
ALYS324
ALYS326

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BWG8
ChainResidueDetails
ATYR47

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon