Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4JQ9

Dihydrolipoyl dehydrogenase of Escherichia coli pyruvate dehydrogenase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0000166	molecular_function	nucleotide binding
B	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0000166	molecular_function	nucleotide binding
C	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0000166	molecular_function	nucleotide binding
D	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
D	0050660	molecular_function	flavin adenine dinucleotide binding
E	0000166	molecular_function	nucleotide binding
E	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
E	0050660	molecular_function	flavin adenine dinucleotide binding
F	0000166	molecular_function	nucleotide binding
F	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
F	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	GLY184
A	ILE185
A	ILE186
A	HOH648
A	HOH824

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	HOH834
A	GLY121
A	ALA122
A	ASN123
A	THR124

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	ASP298
A	LYS299
A	HOH792
A	HOH829

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	ASP281
A	ALA282
A	GLY283
A	HOH736

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 505

Chain	Residue
A	LEU57
A	HIS58
A	TYR352
A	THR353
A	GLU354
A	GLU356
A	HOH675
B	ARG386
B	HOH719

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD A 506

Chain	Residue
A	TYR38
A	GLY43
A	ASN47
A	FAD512
A	HOH646
A	HOH890
D	GLU130

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 507

Chain	Residue
A	GLU369
C	VAL204
C	MET206
C	THR236
C	LYS237
C	VAL238

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 508

Chain	Residue
A	GLU245
A	HOH936
A	HOH952
A	HOH989

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 509

Chain	Residue
A	HOH937
A	HOH938

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 510

Chain	Residue
A	LYS338
A	HIS340
A	HOH985

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 511

Chain	Residue
A	ARG292
A	PHE294
A	ARG296
A	GLY316
A	GLN317
C	GLY254
C	LYS255

site_id	BC3
Number of Residues	37
Details	BINDING SITE FOR RESIDUE FAD A 512

Chain	Residue
A	LEU12
A	GLY13
A	GLY15
A	PRO16
A	ALA17
A	GLU36
A	ARG37
A	TYR38
A	GLY43
A	VAL44
A	CYS45
A	GLY49
A	CYS50
A	LYS54
A	GLY115
A	LEU116
A	GLY117
A	ALA144
A	ALA145
A	GLY146
A	ARG273
A	GLY312
A	ASP313
A	MET319
A	LEU320
A	ALA321
A	HIS322
A	TYR352
A	IMD506
A	HOH603
A	HOH604
A	HOH607
A	HOH623
A	HOH634
A	HOH651
A	HOH662
B	HIS445

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	GLY184
B	ILE185
B	ILE186
B	HOH602
B	HOH900

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 502

Chain	Residue
B	LYS299
B	HOH831
B	HOH845
B	ASP298

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B 503

Chain	Residue
A	LYS61
A	GLU65
A	ASN417
B	LYS61
B	GLU65
B	THR416
B	ASN417
B	HOH719
B	HOH918
B	HOH938

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 504

Chain	Residue
B	GLY121
B	ALA122
B	ASN123
B	THR124
B	HOH791

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 505

Chain	Residue
A	ARG386
B	LEU57
B	TYR352
B	THR353
B	GLU354
B	GLU356
B	HOH603
B	HOH918

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 506

Chain	Residue
B	LYS339
B	HIS340

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 507

Chain	Residue
B	LYS278
B	ASP281
B	ALA282
B	GLY283
B	VAL289
B	HOH863
B	HOH888
B	HOH903

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 508

Chain	Residue
B	TYR38
B	ASN39
B	HOH930
C	TYR38
C	ASN39
C	THR40

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 509

Chain	Residue
B	LYS244
B	HOH926

site_id	CC4
Number of Residues	38
Details	BINDING SITE FOR RESIDUE FAD B 510

Chain	Residue
A	HIS445
B	LEU12
B	GLY13
B	GLY15
B	PRO16
B	ALA17
B	GLU36
B	ARG37
B	TYR38
B	GLY43
B	VAL44
B	CYS45
B	GLY49
B	CYS50
B	LYS54
B	GLY115
B	LEU116
B	GLY117
B	ALA144
B	ALA145
B	GLY146
B	ILE186
B	ARG273
B	LEU280
B	GLY312
B	ASP313
B	MET319
B	LEU320
B	ALA321
B	HIS322
B	TYR352
B	HOH616
B	HOH617
B	HOH619
B	HOH646
B	HOH653
B	HOH846
B	HOH881

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 501

Chain	Residue
C	GLY184
C	ILE185
C	ILE186
C	HOH621
C	HOH710

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 502

Chain	Residue
A	SER373
A	LYS403
C	ARG292
C	PHE294
C	ARG296
C	GLY316
C	GLN317

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 503

Chain	Residue
C	LEU57
C	HIS58
C	TYR352
C	THR353
C	GLU354
C	GLU356
C	HOH659
E	ARG386
E	HOH616

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD C 504

Chain	Residue
B	ASN39
C	TYR38
C	GLY43
C	ASN47
C	FAD510
C	HOH643

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 505

Chain	Residue
B	LYS92
C	HOH719
C	HOH896

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 506

Chain	Residue
C	GLY283
C	HOH887

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 507

Chain	Residue
C	PRO306
C	HIS307
C	HOH917
C	HOH923

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 508

Chain	Residue
C	ARG263
C	HOH890

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 509

Chain	Residue
C	GLY121
C	ALA122
C	ASN123
C	THR124

site_id	DC5
Number of Residues	37
Details	BINDING SITE FOR RESIDUE FAD C 510

Chain	Residue
C	LEU12
C	GLY13
C	GLY15
C	PRO16
C	ALA17
C	GLU36
C	ARG37
C	TYR38
C	GLY43
C	VAL44
C	CYS45
C	GLY49
C	CYS50
C	LYS54
C	GLY115
C	LEU116
C	GLY117
C	ALA144
C	ALA145
C	GLY146
C	ILE186
C	GLY312
C	ASP313
C	MET319
C	LEU320
C	ALA321
C	HIS322
C	TYR352
C	IMD504
C	HOH602
C	HOH606
C	HOH620
C	HOH624
C	HOH636
C	HOH639
E	HIS445
E	PRO446

site_id	DC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 501

Chain	Residue
D	LYS278
D	ASP281
D	ALA282
D	GLY283
D	HOH648
D	HOH676
D	HOH729
D	HOH806

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 502

Chain	Residue
D	ASP298
D	LYS299

site_id	DC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 503

Chain	Residue
D	GLY184
D	ILE185
D	ILE186
D	HOH626
D	HOH647
D	HOH681
D	HOH714
D	HOH857

site_id	DC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 504

Chain	Residue
D	LYS61
D	GLU65
D	ASN417
D	HOH732
F	LYS61
F	GLU65
F	THR416
F	ASN417

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 505

Chain	Residue
D	LYS338
D	HIS340
D	HOH767
D	HOH839

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 506

Chain	Residue
D	LEU57
D	HIS58
D	TYR352
D	THR353
D	GLU356
D	HOH629
F	ARG386

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 507

Chain	Residue
A	GLU130
D	ARG37
D	TYR38
D	VAL44
D	FAD510
D	HOH630

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 508

Chain	Residue
D	GLY121
D	ALA122
D	ASN123
D	THR124
D	HOH828

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 509

Chain	Residue
D	ARG263
D	HOH705
D	HOH866

site_id	EC6
Number of Residues	40
Details	BINDING SITE FOR RESIDUE FAD D 510

Chain	Residue
D	LEU12
D	GLY13
D	GLY15
D	PRO16
D	ALA17
D	GLU36
D	ARG37
D	TYR38
D	GLY43
D	VAL44
D	CYS45
D	GLY49
D	CYS50
D	LYS54
D	GLY115
D	LEU116
D	GLY117
D	ALA144
D	ALA145
D	GLY146
D	ILE186
D	ARG273
D	LEU280
D	GLY312
D	ASP313
D	MET319
D	LEU320
D	ALA321
D	HIS322
D	TYR352
D	GOL507
D	HOH603
D	HOH606
D	HOH630
D	HOH631
D	HOH643
D	HOH698
D	HOH710
F	HIS445
F	HOH622

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 501

Chain	Residue
E	SER373
E	HOH749
F	ARG292
F	ARG296
F	GLY316
F	GLN317

site_id	EC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E 502

Chain	Residue
E	GLY184
E	ILE185
E	ILE186
E	HOH639
E	HOH667
E	HOH706
E	HOH717

site_id	EC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 E 503

Chain	Residue
C	LYS61
C	GLU65
C	THR416
C	ASN417
E	LYS61
E	GLU65
E	THR416
E	ASN417
E	HOH616
E	HOH732

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 504

Chain	Residue
C	ARG386
E	TYR352
E	THR353
E	GLU354
E	GLU356
E	HOH613

site_id	FC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 505

Chain	Residue
C	TYR19
C	CYS45
C	ILE51
E	ALA383
E	GLY385
E	HIS445
E	HOH701

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD E 506

Chain	Residue
E	TYR38
E	GLY43
E	ASN47
E	FAD511
E	HOH817

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 507

Chain	Residue
E	ASP298
E	LYS299

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 508

Chain	Residue
E	ARG296
E	GLN317
E	HOH797
F	GLY254
F	LYS255

site_id	FC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 509

Chain	Residue
E	ASN123
E	THR124
E	HOH799

site_id	FC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 510

Chain	Residue
E	ASP281
E	ALA282
E	GLY283
E	HOH646

site_id	FC8
Number of Residues	39
Details	BINDING SITE FOR RESIDUE FAD E 511

Chain	Residue
C	HIS445
E	LEU12
E	GLY13
E	GLY15
E	PRO16
E	ALA17
E	GLU36
E	ARG37
E	TYR38
E	GLY43
E	VAL44
E	CYS45
E	GLY49
E	CYS50
E	LYS54
E	GLY115
E	LEU116
E	GLY117
E	ALA144
E	ALA145
E	GLY146
E	ILE186
E	ARG273
E	LEU280
E	GLY312
E	ASP313
E	MET319
E	LEU320
E	ALA321
E	HIS322
E	TYR352
E	IMD506
E	HOH603
E	HOH612
E	HOH622
E	HOH642
E	HOH657
E	HOH734
E	HOH807

site_id	FC9
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD F 501

Chain	Residue
D	HIS445
F	LEU12
F	GLY13
F	GLY15
F	PRO16
F	ALA17
F	GLU36
F	ARG37
F	GLY43
F	VAL44
F	CYS45
F	GLY49
F	CYS50
F	LYS54
F	GLY115
F	LEU116
F	GLY117
F	ALA144
F	ALA145
F	GLY146
F	ILE186
F	ARG273
F	GLY312
F	ASP313
F	MET319
F	LEU320
F	ALA321
F	HIS322
F	TYR352
F	HOH604
F	HOH606
F	HOH609
F	HOH611
F	HOH643

site_id	GC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 502

Chain	Residue
F	GLY184
F	ILE185
F	ILE186
F	HOH616
F	HOH704

site_id	GC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL F 503

Chain	Residue
D	ARG386
F	LEU57
F	HIS58
F	LYS61
F	TYR352
F	THR353
F	GLU354
F	GLU356
F	HOH635

site_id	GC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL F 504

Chain	Residue
E	GLU369
F	VAL204
F	GLU205
F	MET206
F	LYS237
F	VAL238
F	ILE271

site_id	GC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL F 505

Chain	Residue
F	ARG263

site_id	GC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 507

Chain	Residue
F	ASP298
F	LYS299

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGvCLnvGCIP

Chain	Residue	Details
A	GLY42-PRO52

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)