4JOS
Crystal structure of a putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Francisella philomiragia ATCC 25017 (Target NYSGRC-029335)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| B | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ADE A 301 |
| Chain | Residue |
| A | ALA78 |
| A | ALA198 |
| A | GLY79 |
| A | GLN150 |
| A | PHE151 |
| A | VAL152 |
| A | GLU171 |
| A | MSE172 |
| A | SER195 |
| A | ASP196 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | SER154 |
| A | ALA155 |
| A | GLU156 |
| A | ASP199 |
| A | GLY200 |
| A | HOH558 |
| A | HOH616 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 303 |
| Chain | Residue |
| A | ASP83 |
| A | ASP88 |
| A | HOH499 |
| A | HOH588 |
| B | ASN137 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 304 |
| Chain | Residue |
| A | LEU21 |
| A | HOH538 |
| A | HOH577 |
| A | HOH583 |
| A | HOH596 |
| A | HOH612 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADE B 301 |
| Chain | Residue |
| B | VAL77 |
| B | ALA78 |
| B | GLY79 |
| B | GLN150 |
| B | PHE151 |
| B | VAL152 |
| B | GLU171 |
| B | MSE172 |
| B | SER195 |
| B | ASP196 |
| B | ALA198 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 302 |
| Chain | Residue |
| B | SER154 |
| B | ALA155 |
| B | ASP199 |
| B | GLY200 |
| B | HOH448 |
| B | HOH542 |
| B | HOH575 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 303 |
| Chain | Residue |
| B | LEU138 |
| B | ASN139 |
| B | LEU140 |
| B | HOH418 |
| B | HOH520 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 304 |
| Chain | Residue |
| B | GLU118 |
| B | GLU164 |
| B | PHE165 |
| B | HOH420 |
| B | HOH470 |
| B | HOH492 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 305 |
| Chain | Residue |
| B | ASN32 |
| B | TYR48 |
| B | HOH484 |
