4JLZ
Structure of porcine cGAS in complex with bound UTP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | HIS367 |
| A | CYS373 |
| A | CYS374 |
| A | CYS381 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | ASP202 |
| A | UTP503 |
| A | HOH649 |
| A | HOH743 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UTP A 503 |
| Chain | Residue |
| A | SER188 |
| A | GLU191 |
| A | ASP202 |
| A | ARG353 |
| A | SER412 |
| A | TYR413 |
| A | LYS416 |
| A | MG502 |
| A | HOH604 |
| A | HOH628 |
| A | HOH652 |
| A | HOH695 |
| A | HOH743 |
| A | GLY187 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 501 |
| Chain | Residue |
| B | HIS367 |
| B | CYS373 |
| B | CYS374 |
| B | CYS381 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 502 |
| Chain | Residue |
| B | ASP202 |
| B | UTP503 |
| B | HOH632 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UTP B 503 |
| Chain | Residue |
| B | GLY187 |
| B | SER188 |
| B | ASP202 |
| B | ARG353 |
| B | SER412 |
| B | TYR413 |
| B | LYS416 |
| B | ASN459 |
| B | MG502 |
| B | HOH629 |
| B | HOH632 |
| B | HOH642 |
| B | HOH651 |
| B | HOH660 |
| B | HOH690 |
| B | HOH695 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23722159 |
| Chain | Residue | Details |
| A | THR186 | |
| A | CYS381 | |
| A | LYS391 | |
| A | SER412 | |
| B | THR186 | |
| B | SER188 | |
| B | GLU200 | |
| B | ASP202 | |
| B | ASP296 | |
| B | GLU360 | |
| B | HIS367 | |
| A | SER188 | |
| B | CYS373 | |
| B | CYS374 | |
| B | CYS381 | |
| B | LYS391 | |
| B | SER412 | |
| A | GLU200 | |
| A | ASP202 | |
| A | ASP296 | |
| A | GLU360 | |
| A | HIS367 | |
| A | CYS373 | |
| A | CYS374 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS339 | |
| A | ARG353 | |
| B | LYS339 | |
| B | ARG353 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Arginine-anchor => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | ARG230 | |
| B | ARG230 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by CASP3 => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | ASP296 | |
| B | ASP296 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | GLU165 | |
| B | GLU165 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | SER188 | |
| A | SER280 | |
| A | SER412 | |
| B | SER188 | |
| B | SER280 | |
| B | SER412 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | TYR190 | |
| B | TYR190 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | GLU261 | |
| B | GLU261 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS361 | |
| A | LYS371 | |
| A | LYS391 | |
| B | LYS361 | |
| B | LYS371 | |
| B | LYS391 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS483 | |
| B | LYS483 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | CYS381 | |
| A | CYS382 | |
| A | CYS451 | |
| B | CYS381 | |
| B | CYS382 | |
| B | CYS451 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | LYS206 | |
| A | LYS371 | |
| B | LYS206 | |
| B | LYS371 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | LYS260 | |
| A | LYS398 | |
| A | LYS399 | |
| B | LYS260 | |
| B | LYS398 | |
| B | LYS399 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | LYS324 | |
| B | LYS324 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS361 | |
| B | LYS361 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS388 | |
| A | LYS391 | |
| B | LYS388 | |
| B | LYS391 |
