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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4JLZ

Structure of porcine cGAS in complex with bound UTP

Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 501
ChainResidue
AHIS367
ACYS373
ACYS374
ACYS381
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 502
ChainResidue
AASP202
AUTP503
AHOH649
AHOH743
site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE UTP A 503
ChainResidue
ASER188
AGLU191
AASP202
AARG353
ASER412
ATYR413
ALYS416
AMG502
AHOH604
AHOH628
AHOH652
AHOH695
AHOH743
AGLY187
site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 501
ChainResidue
BHIS367
BCYS373
BCYS374
BCYS381
site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 502
ChainResidue
BASP202
BUTP503
BHOH632
site_idAC6
Number of Residues16
DetailsBINDING SITE FOR RESIDUE UTP B 503
ChainResidue
BGLY187
BSER188
BASP202
BARG353
BSER412
BTYR413
BLYS416
BASN459
BMG502
BHOH629
BHOH632
BHOH642
BHOH651
BHOH660
BHOH690
BHOH695
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues132
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"23722159","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues82
DetailsRegion: {"description":"Interaction with collided ribosomes","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues10
DetailsMotif: {"description":"Nuclear export signal","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues44
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23722159","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsSite: {"description":"Arginine-anchor","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsSite: {"description":"Cleavage; by CASP3","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues6
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

249524

PDB entries from 2026-02-18

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