4JFV
Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(methylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004560 | molecular_function | alpha-L-fucosidase activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0016139 | biological_process | glycoside catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004560 | molecular_function | alpha-L-fucosidase activity |
| B | 0005764 | cellular_component | lysosome |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006004 | biological_process | fucose metabolic process |
| B | 0016139 | biological_process | glycoside catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0004560 | molecular_function | alpha-L-fucosidase activity |
| C | 0005764 | cellular_component | lysosome |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006004 | biological_process | fucose metabolic process |
| C | 0016139 | biological_process | glycoside catabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| D | 0004560 | molecular_function | alpha-L-fucosidase activity |
| D | 0005764 | cellular_component | lysosome |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006004 | biological_process | fucose metabolic process |
| D | 0016139 | biological_process | glycoside catabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | ARG262 |
| A | ARG271 |
| A | HIS272 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | GLN354 |
| A | ALA355 |
| A | ASP356 |
| A | HOH783 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IMD A 503 |
| Chain | Residue |
| A | TYR168 |
| A | PHE359 |
| A | TRP117 |
| A | MET120 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IMD A 504 |
| Chain | Residue |
| A | ALA387 |
| A | ARG399 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD A 505 |
| Chain | Residue |
| A | GLY83 |
| A | ASN402 |
| A | HOH767 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IMD A 506 |
| Chain | Residue |
| A | THR422 |
| A | ILE426 |
| A | GLU444 |
| A | THR446 |
| A | ASN448 |
| A | GLU449 |
| A | TYR450 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IMD A 507 |
| Chain | Residue |
| A | ARG417 |
| C | LYS111 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE H57 A 508 |
| Chain | Residue |
| A | HIS66 |
| A | GLU87 |
| A | TRP88 |
| A | HIS135 |
| A | TYR178 |
| A | ASP229 |
| A | TRP232 |
| A | GLU288 |
| A | TRP316 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | LYS90 |
| B | PRO96 |
| B | ALA97 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD B 502 |
| Chain | Residue |
| B | ILE65 |
| B | TRP117 |
| B | MET120 |
| B | TYR168 |
| B | PHE359 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IMD B 503 |
| Chain | Residue |
| B | TRP232 |
| B | ARG262 |
| B | ARG271 |
| B | HIS272 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IMD B 504 |
| Chain | Residue |
| B | ALA387 |
| B | ARG399 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE H57 B 505 |
| Chain | Residue |
| B | HIS66 |
| B | GLU87 |
| B | TRP88 |
| B | HIS135 |
| B | TYR178 |
| B | ASP229 |
| B | TRP232 |
| B | GLU288 |
| B | TRP316 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 501 |
| Chain | Residue |
| C | TRP232 |
| C | ARG262 |
| C | ARG271 |
| C | HIS272 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD C 502 |
| Chain | Residue |
| C | ILE65 |
| C | TRP117 |
| C | MET120 |
| C | TYR168 |
| C | PHE359 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE H57 C 503 |
| Chain | Residue |
| C | HIS66 |
| C | GLU87 |
| C | TRP88 |
| C | HIS135 |
| C | TYR178 |
| C | TRP227 |
| C | ASP229 |
| C | TRP232 |
| C | GLU288 |
| C | TRP316 |
| C | HOH753 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 501 |
| Chain | Residue |
| D | GLU288 |
| D | ARG289 |
| D | ASN314 |
| D | H57504 |
| D | HOH688 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD D 502 |
| Chain | Residue |
| D | ILE65 |
| D | TRP117 |
| D | MET120 |
| D | TYR168 |
| D | PHE359 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE IMD D 503 |
| Chain | Residue |
| D | THR422 |
| D | ILE426 |
| D | THR427 |
| D | GLU444 |
| D | THR446 |
| D | ASN448 |
| D | TYR450 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE H57 D 504 |
| Chain | Residue |
| D | ASP229 |
| D | GLU288 |
| D | TRP316 |
| D | SO4501 |
| D | HIS66 |
| D | GLU87 |
| D | TRP88 |
| D | HIS135 |
| D | TYR178 |
