4JFV
Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(methylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004560 | molecular_function | alpha-L-fucosidase activity |
A | 0005764 | cellular_component | lysosome |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006004 | biological_process | fucose metabolic process |
A | 0016139 | biological_process | glycoside catabolic process |
A | 0016787 | molecular_function | hydrolase activity |
B | 0004560 | molecular_function | alpha-L-fucosidase activity |
B | 0005764 | cellular_component | lysosome |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006004 | biological_process | fucose metabolic process |
B | 0016139 | biological_process | glycoside catabolic process |
B | 0016787 | molecular_function | hydrolase activity |
C | 0004560 | molecular_function | alpha-L-fucosidase activity |
C | 0005764 | cellular_component | lysosome |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0006004 | biological_process | fucose metabolic process |
C | 0016139 | biological_process | glycoside catabolic process |
C | 0016787 | molecular_function | hydrolase activity |
D | 0004560 | molecular_function | alpha-L-fucosidase activity |
D | 0005764 | cellular_component | lysosome |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0006004 | biological_process | fucose metabolic process |
D | 0016139 | biological_process | glycoside catabolic process |
D | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 501 |
Chain | Residue |
A | ARG262 |
A | ARG271 |
A | HIS272 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 502 |
Chain | Residue |
A | GLN354 |
A | ALA355 |
A | ASP356 |
A | HOH783 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE IMD A 503 |
Chain | Residue |
A | TYR168 |
A | PHE359 |
A | TRP117 |
A | MET120 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE IMD A 504 |
Chain | Residue |
A | ALA387 |
A | ARG399 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE IMD A 505 |
Chain | Residue |
A | GLY83 |
A | ASN402 |
A | HOH767 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE IMD A 506 |
Chain | Residue |
A | THR422 |
A | ILE426 |
A | GLU444 |
A | THR446 |
A | ASN448 |
A | GLU449 |
A | TYR450 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE IMD A 507 |
Chain | Residue |
A | ARG417 |
C | LYS111 |
site_id | AC8 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE H57 A 508 |
Chain | Residue |
A | HIS66 |
A | GLU87 |
A | TRP88 |
A | HIS135 |
A | TYR178 |
A | ASP229 |
A | TRP232 |
A | GLU288 |
A | TRP316 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 501 |
Chain | Residue |
B | LYS90 |
B | PRO96 |
B | ALA97 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE IMD B 502 |
Chain | Residue |
B | ILE65 |
B | TRP117 |
B | MET120 |
B | TYR168 |
B | PHE359 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE IMD B 503 |
Chain | Residue |
B | TRP232 |
B | ARG262 |
B | ARG271 |
B | HIS272 |
site_id | BC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE IMD B 504 |
Chain | Residue |
B | ALA387 |
B | ARG399 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE H57 B 505 |
Chain | Residue |
B | HIS66 |
B | GLU87 |
B | TRP88 |
B | HIS135 |
B | TYR178 |
B | ASP229 |
B | TRP232 |
B | GLU288 |
B | TRP316 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 501 |
Chain | Residue |
C | TRP232 |
C | ARG262 |
C | ARG271 |
C | HIS272 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE IMD C 502 |
Chain | Residue |
C | ILE65 |
C | TRP117 |
C | MET120 |
C | TYR168 |
C | PHE359 |
site_id | BC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE H57 C 503 |
Chain | Residue |
C | HIS66 |
C | GLU87 |
C | TRP88 |
C | HIS135 |
C | TYR178 |
C | TRP227 |
C | ASP229 |
C | TRP232 |
C | GLU288 |
C | TRP316 |
C | HOH753 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 D 501 |
Chain | Residue |
D | GLU288 |
D | ARG289 |
D | ASN314 |
D | H57504 |
D | HOH688 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE IMD D 502 |
Chain | Residue |
D | ILE65 |
D | TRP117 |
D | MET120 |
D | TYR168 |
D | PHE359 |
site_id | CC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE IMD D 503 |
Chain | Residue |
D | THR422 |
D | ILE426 |
D | THR427 |
D | GLU444 |
D | THR446 |
D | ASN448 |
D | TYR450 |
site_id | CC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE H57 D 504 |
Chain | Residue |
D | ASP229 |
D | GLU288 |
D | TRP316 |
D | SO4501 |
D | HIS66 |
D | GLU87 |
D | TRP88 |
D | HIS135 |
D | TYR178 |