4JFT
Crystal structure of a bacterial fucosidase with iminosugar inhibitor N-desmethyl-4-epi-(+)-Codonopsinine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004560 | molecular_function | alpha-L-fucosidase activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0016139 | biological_process | glycoside catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0004560 | molecular_function | alpha-L-fucosidase activity |
| B | 0005764 | cellular_component | lysosome |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006004 | biological_process | fucose metabolic process |
| B | 0016139 | biological_process | glycoside catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1KN A 501 |
| Chain | Residue |
| A | HIS66 |
| A | GLU87 |
| A | TRP88 |
| A | HIS135 |
| A | TYR178 |
| A | ASP229 |
| A | TRP232 |
| A | TRP316 |
| A | IMD506 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | ARG262 |
| A | ARG271 |
| A | HIS272 |
| A | IMD506 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | LYS90 |
| A | PRO96 |
| A | ALA97 |
| A | HOH792 |
| A | HOH796 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IMD A 504 |
| Chain | Residue |
| A | TRP117 |
| A | MET120 |
| A | TYR168 |
| A | PHE359 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD A 505 |
| Chain | Residue |
| A | ARG399 |
| A | ASP403 |
| A | HOH733 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD A 506 |
| Chain | Residue |
| A | TRP232 |
| A | 1KN501 |
| A | SO4502 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 507 |
| Chain | Residue |
| A | ASN169 |
| A | GLY172 |
| A | ASP174 |
| A | LYS224 |
| A | HOH604 |
| A | HOH761 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 508 |
| Chain | Residue |
| A | ALA71 |
| A | TYR318 |
| A | GLN354 |
| A | ALA355 |
| A | ASP356 |
| A | HOH689 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 509 |
| Chain | Residue |
| A | LYS145 |
| A | TYR146 |
| A | ASN211 |
| A | LYS214 |
| A | GLU215 |
| A | THR218 |
| A | ARG219 |
| B | GLU252 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1KN B 501 |
| Chain | Residue |
| B | HIS66 |
| B | GLU87 |
| B | TRP88 |
| B | HIS135 |
| B | TYR178 |
| B | TRP227 |
| B | ASP229 |
| B | TRP232 |
| B | TRP316 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | TRP232 |
| B | ARG262 |
| B | ARG271 |
| B | HIS272 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 503 |
| Chain | Residue |
| B | VAL81 |
| B | TYR82 |
| B | GLY83 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IMD B 504 |
| Chain | Residue |
| B | TRP117 |
| B | MET120 |
| B | TYR168 |
| B | PHE359 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IMD B 505 |
| Chain | Residue |
| B | HOH781 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IMD B 506 |
| Chain | Residue |
| B | GLN302 |
| B | HOH708 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 507 |
| Chain | Residue |
| B | GLN354 |
| B | ASP356 |
| B | ASP358 |
| B | PHE359 |
| B | PRO361 |
| B | HOH773 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 508 |
| Chain | Residue |
| A | PRO143 |
| A | LYS145 |
| A | ALA152 |
| A | HOH692 |
| B | PRO255 |
| B | HOH671 |
