Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4JFP

A2 HLA complex with G4A heteroclitic variant of Melanoma peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0000139	cellular_component	Golgi membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010977	biological_process	negative regulation of neuron projection development
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0016020	cellular_component	membrane
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0031905	cellular_component	early endosome lumen
E	0032092	biological_process	positive regulation of protein binding
E	0033077	biological_process	T cell differentiation in thymus
E	0034756	biological_process	regulation of iron ion transport
E	0035580	cellular_component	specific granule lumen
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0055038	cellular_component	recycling endosome membrane
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0070062	cellular_component	extracellular exosome
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1900121	biological_process	negative regulation of receptor binding
E	1900122	biological_process	positive regulation of receptor binding
E	1904434	biological_process	positive regulation of ferrous iron binding
E	1904437	biological_process	positive regulation of transferrin receptor binding
E	1904724	cellular_component	tertiary granule lumen
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 301

Chain	Residue
A	ALA40
A	ALA41
A	SER88

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	SER13
A	ARG75
A	HOH431
A	HOH442
A	HOH544

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 303

Chain	Residue
A	PRO20
A	ARG21
A	SER38
A	ASP39
B	MET0
B	HOH435
A	GLU19

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ASP122
A	TYR123
A	ILE124
A	ALA125
A	THR134
A	ALA136
A	HOH467
A	HOH537

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	ARG6
A	PHE8
A	TYR27
A	ASP29
A	ASP30
B	HOH429

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 301

Chain	Residue
B	LEU40
B	ASN42
B	GLY43
B	GLU77
B	ALA79
B	LYS94

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 302

Chain	Residue
B	ARG3
B	THR4
B	LYS6
B	GLY29

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GOL B 303

Chain	Residue
A	ARG234
A	GLN242
B	TYR10
B	SER11
B	HIS13
B	PRO14
B	TRP95
B	ASP96
B	ARG97
B	MET99
B	EDO305
B	HOH434
B	HOH479

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 304

Chain	Residue
A	ARG234
B	GLN8
B	VAL9
B	LYS94
B	ASP96
B	MET99
B	HOH466
B	HOH475

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 305

Chain	Residue
A	HIS188
A	THR190
B	ARG97
B	ASP98
B	GOL303

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 306

Chain	Residue
B	ASN17
B	GLU74
B	HOH485
D	HIS191
D	HIS192
D	ALA193
D	HOH507

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 307

Chain	Residue
B	ASP34
B	ILE35
B	ASN83
B	HIS84
B	HOH427

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 301

Chain	Residue
D	TYR27
D	GLN32
D	PRO235
D	HOH472
E	SER52

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 302

Chain	Residue
D	HIS188
D	THR190
E	ARG97
E	ASP98
E	EDO103

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE D 303

Chain	Residue
D	ARG35
D	ASP39
D	ALA40
D	ALA41
D	GLU46
D	GLN87
D	SER88
D	HOH430
E	MET0

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 101

Chain	Residue
E	VAL9
E	MET99
E	HOH427
E	HOH432
D	VAL231
D	ARG234
E	GLN8

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 102

Chain	Residue
B	GLU74
E	LYS94
E	TRP95
E	ASP96
E	ARG97
E	HOH437

site_id	BC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO E 103

Chain	Residue
D	LEU206
D	ARG234
D	GLN242
D	EDO302
E	TYR10
E	SER11
E	HIS13
E	PRO14
E	HOH409
E	HOH442

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN2
D	THR143
D	LYS146
D	TYR171
E	GLN2
A	TYR84
A	THR143
A	LYS146
A	TYR171
D	TYR7
D	THR73
D	TYR84

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE1
E	ILE1
D	TYR116
D	TYR159

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS19
E	LYS58
E	LYS91
E	LYS94
B	LYS41
B	LYS48
B	LYS58
B	LYS91
B	LYS94
E	LYS19
E	LYS41
E	LYS48

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN86
D	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)