4JF6
Structure of OXA-23 at pH 7.0
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008658 | molecular_function | penicillin binding |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 301 |
| Chain | Residue |
| A | HIS41 |
| A | HIS41 |
| A | ASP45 |
| A | ASP45 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 302 |
| Chain | Residue |
| A | LEU63 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 303 |
| Chain | Residue |
| A | ASN66 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 304 |
| Chain | Residue |
| A | ASN98 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 306 |
| Chain | Residue |
| A | TRP219 |
| A | ARG259 |
| A | THR217 |
| A | GLY218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"24012371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30530607","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6N6U","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4JF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24012371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30530607","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6N6U","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4JF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"24012371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30530607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35420470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JF5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T7G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
