4JF4
OXA-23 meropenem complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008658 | molecular_function | penicillin binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071555 | biological_process | cell wall organization |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008658 | molecular_function | penicillin binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 301 |
| Chain | Residue |
| A | ALA256 |
| A | HOH474 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MER A 302 |
| Chain | Residue |
| A | GLY218 |
| A | TRP219 |
| A | ALA256 |
| A | ARG259 |
| A | HOH410 |
| A | HOH474 |
| A | ALA78 |
| A | SER79 |
| A | PHE110 |
| A | LEU125 |
| A | SER126 |
| A | VAL128 |
| A | THR217 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MER B 301 |
| Chain | Residue |
| B | ALA78 |
| B | SER79 |
| B | PHE110 |
| B | TRP113 |
| B | SER126 |
| B | VAL128 |
| B | LEU166 |
| B | THR217 |
| B | GLY218 |
| B | TRP219 |
| B | ALA256 |
| B | ARG259 |
| B | HOH423 |
| B | HOH444 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:24012371, ECO:0000269|PubMed:30530607, ECO:0000312|PDB:6N6U, ECO:0007744|PDB:4JF4, ECO:0007744|PDB:6N6V |
| Chain | Residue | Details |
| A | SER79 | |
| B | SER79 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24012371, ECO:0000269|PubMed:30530607, ECO:0000312|PDB:6N6U, ECO:0007744|PDB:4JF4, ECO:0007744|PDB:6N6V |
| Chain | Residue | Details |
| A | SER79 | |
| A | THR217 | |
| A | TRP219 | |
| A | ARG259 | |
| B | SER79 | |
| B | THR217 | |
| B | TRP219 | |
| B | ARG259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P13661 |
| Chain | Residue | Details |
| A | LYS82 | |
| A | SER126 | |
| B | LYS82 | |
| B | SER126 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:24012371, ECO:0000269|PubMed:30530607, ECO:0000269|PubMed:35420470, ECO:0007744|PDB:4JF5, ECO:0007744|PDB:4JF6, ECO:0007744|PDB:6N6T, ECO:0007744|PDB:6N6W, ECO:0007744|PDB:7T7G |
| Chain | Residue | Details |
| A | LYS82 | |
| B | LYS82 |
