4JDI

Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide S peptide substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ANP A 1000

Chain	Residue
A	ILE327
A	GLU396
A	PHE397
A	LEU398
A	ASP444
A	LEU447
A	ASP458
A	MG1001
A	MG1002
A	HOH1111
A	HOH1164
A	GLY330
A	HOH1212
A	HOH1232
A	HOH1234
B	ARG-1
A	SER331
A	THR332
A	GLY333
A	VAL335
A	ALA348
A	LYS350
A	MET395

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1001

Chain	Residue
A	ASP458
A	ANP1000
A	HOH1102
A	HOH1123
A	HOH1186

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	ASP458
A	ANP1000
A	HOH1232
A	HOH1233
A	HOH1234

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK

Chain	Residue	Details
A	ILE327-LYS351

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP440

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU

Chain	Residue	Details
A	ILE327
A	LYS350

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU

Chain	Residue	Details
A	GLU396
A	ASP458

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER291

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|Ref.32, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SEP474

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