4JDH
Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide T peptide substrate
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR CHAIN B OF PAKTIDE T |
| Chain | Residue |
| A | GLY330 |
| A | GLU415 |
| A | ASP440 |
| A | LYS442 |
| A | SER443 |
| A | ASP444 |
| A | PHE461 |
| A | SEP474 |
| A | LEU475 |
| A | VAL476 |
| A | GLY477 |
| A | SER331 |
| A | THR478 |
| A | PRO479 |
| A | TYR480 |
| A | TRP481 |
| A | ARG489 |
| A | GLU507 |
| A | PRO520 |
| A | ALA575 |
| A | SER342 |
| A | GLN358 |
| A | ARG359 |
| A | LEU362 |
| A | THR404 |
| A | ASN413 |
| A | GLU414 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK |
| Chain | Residue | Details |
| A | ILE327-LYS351 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ASP440 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU |
| Chain | Residue | Details |
| A | ILE327 | |
| A | LYS350 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU |
| Chain | Residue | Details |
| A | GLU396 | |
| A | ASP458 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER291 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|Ref.32, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SEP474 |
