4JAQ
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009715 | biological_process | chalcone biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0034081 | cellular_component | polyketide synthase complex |
| A | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009715 | biological_process | chalcone biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0034081 | cellular_component | polyketide synthase complex |
| B | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009715 | biological_process | chalcone biosynthetic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0034081 | cellular_component | polyketide synthase complex |
| C | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0008610 | biological_process | lipid biosynthetic process |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009715 | biological_process | chalcone biosynthetic process |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0034081 | cellular_component | polyketide synthase complex |
| D | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 14V D 401 |
| Chain | Residue |
| D | PHE28 |
| D | LEU239 |
| D | SER312 |
| D | PRO341 |
| D | LEU56 |
| D | VAL106 |
| D | GLY137 |
| D | CYS138 |
| D | THR171 |
| D | PHE188 |
| D | MET228 |
| D | TRP230 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 14V A 401 |
| Chain | Residue |
| A | PHE28 |
| A | TYR59 |
| A | VAL106 |
| A | GLY137 |
| A | CYS138 |
| A | SER169 |
| A | THR171 |
| A | MET228 |
| A | TRP230 |
| A | LEU241 |
| A | PRO341 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE COA C 401 |
| Chain | Residue |
| C | ALA44 |
| C | VAL179 |
| C | SER180 |
| C | VAL183 |
| C | MET228 |
| C | LEU241 |
| C | PRO243 |
| C | GLY279 |
| C | PRO281 |
| C | LYS282 |
| C | MET339 |
| C | HOH625 |
| C | HOH647 |
| C | HOH656 |
| C | HOH714 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PLM C 402 |
| Chain | Residue |
| C | VAL106 |
| C | GLY137 |
| C | CYS138 |
| C | CYS168 |
| C | THR171 |
| C | PHE188 |
| C | MET228 |
| C | TRP230 |
| C | SER312 |
| C | HOH715 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE COA B 401 |
| Chain | Residue |
| B | ARG40 |
| B | ALA44 |
| B | VAL179 |
| B | SER180 |
| B | VAL183 |
| B | MET228 |
| B | LEU241 |
| B | PRO243 |
| B | GLY279 |
| B | PRO281 |
| B | LYS282 |
| B | VAL283 |
| B | MET339 |
| B | HOH641 |
| B | HOH677 |
| B | HOH721 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PLM B 402 |
| Chain | Residue |
| B | ILE21 |
| B | LEU56 |
| B | VAL106 |
| B | CYS138 |
| B | THR171 |
| B | PHE188 |
| B | TRP230 |
| B | SER312 |
| B | HOH722 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23615910","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23615910","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
