4JAQ

Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008610	biological_process	lipid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0009715	biological_process	chalcone biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030639	biological_process	polyketide biosynthetic process
A	0034081	cellular_component	polyketide synthase complex
A	0071770	biological_process	DIM/DIP cell wall layer assembly
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008610	biological_process	lipid biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0009715	biological_process	chalcone biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0030639	biological_process	polyketide biosynthetic process
B	0034081	cellular_component	polyketide synthase complex
B	0071770	biological_process	DIM/DIP cell wall layer assembly
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008610	biological_process	lipid biosynthetic process
C	0009058	biological_process	biosynthetic process
C	0009715	biological_process	chalcone biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0030639	biological_process	polyketide biosynthetic process
C	0034081	cellular_component	polyketide synthase complex
C	0071770	biological_process	DIM/DIP cell wall layer assembly
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0008610	biological_process	lipid biosynthetic process
D	0009058	biological_process	biosynthetic process
D	0009715	biological_process	chalcone biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0030639	biological_process	polyketide biosynthetic process
D	0034081	cellular_component	polyketide synthase complex
D	0071770	biological_process	DIM/DIP cell wall layer assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 14V D 401

Chain	Residue
D	PHE28
D	LEU239
D	SER312
D	PRO341
D	LEU56
D	VAL106
D	GLY137
D	CYS138
D	THR171
D	PHE188
D	MET228
D	TRP230

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 14V A 401

Chain	Residue
A	PHE28
A	TYR59
A	VAL106
A	GLY137
A	CYS138
A	SER169
A	THR171
A	MET228
A	TRP230
A	LEU241
A	PRO341

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE COA C 401

Chain	Residue
C	ALA44
C	VAL179
C	SER180
C	VAL183
C	MET228
C	LEU241
C	PRO243
C	GLY279
C	PRO281
C	LYS282
C	MET339
C	HOH625
C	HOH647
C	HOH656
C	HOH714

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLM C 402

Chain	Residue
C	VAL106
C	GLY137
C	CYS138
C	CYS168
C	THR171
C	PHE188
C	MET228
C	TRP230
C	SER312
C	HOH715

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE COA B 401

Chain	Residue
B	ARG40
B	ALA44
B	VAL179
B	SER180
B	VAL183
B	MET228
B	LEU241
B	PRO243
B	GLY279
B	PRO281
B	LYS282
B	VAL283
B	MET339
B	HOH641
B	HOH677
B	HOH721

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PLM B 402

Chain	Residue
B	ILE21
B	LEU56
B	VAL106
B	CYS138
B	THR171
B	PHE188
B	TRP230
B	SER312
B	HOH722

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:23615910

Chain	Residue	Details
D	CYS138
A	CYS138
C	CYS138
B	CYS138

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:23615910

Chain	Residue	Details
D	SER180
C	LEU241
C	HIS277
C	SER312
B	SER180
B	LEU241
B	HIS277
B	SER312
D	LEU241
D	HIS277
D	SER312
A	SER180
A	LEU241
A	HIS277
A	SER312
C	SER180

---