4JA7
Rat PP5 co-crystallized with P5SA-2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001933 | biological_process | negative regulation of protein phosphorylation |
| A | 0001965 | molecular_function | G-protein alpha-subunit binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0010288 | biological_process | response to lead ion |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0030291 | molecular_function | protein serine/threonine kinase inhibitor activity |
| A | 0030544 | molecular_function | Hsp70 protein binding |
| A | 0031072 | molecular_function | heat shock protein binding |
| A | 0031435 | molecular_function | mitogen-activated protein kinase kinase kinase binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043204 | cellular_component | perikaryon |
| A | 0043409 | biological_process | negative regulation of MAPK cascade |
| A | 0043531 | molecular_function | ADP binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0051879 | molecular_function | Hsp90 protein binding |
| A | 0070262 | biological_process | peptidyl-serine dephosphorylation |
| A | 0070301 | biological_process | cellular response to hydrogen peroxide |
| A | 0071276 | biological_process | cellular response to cadmium ion |
| A | 0101031 | cellular_component | protein folding chaperone complex |
| A | 1904550 | biological_process | response to arachidonate |
| A | 1990635 | cellular_component | proximal dendrite |
| A | 2000324 | biological_process | positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | ASP271 |
| A | ASN303 |
| A | HIS352 |
| A | HIS427 |
| A | MG502 |
| A | HOH700 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | MG501 |
| A | HOH610 |
| A | ASP242 |
| A | HIS244 |
| A | ASP271 |
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| A | LEU300-GLU305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P53041","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26182372","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JA7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P53041","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26182372","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JA9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
