Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 301 |
Chain | Residue |
A | HIS201 |
A | HIS205 |
A | HIS211 |
B | THR255 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 302 |
Chain | Residue |
A | HIS151 |
A | ASP153 |
A | HIS166 |
A | HIS179 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 303 |
Chain | Residue |
A | GLY159 |
A | GLY161 |
A | VAL163 |
A | ASP181 |
A | GLU184 |
A | ASP158 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 304 |
Chain | Residue |
A | ASP141 |
A | GLY173 |
A | ASN175 |
A | ASP177 |
A | HOH401 |
A | HOH443 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 305 |
Chain | Residue |
A | ASP107 |
A | ASP182 |
A | GLU184 |
A | HOH405 |
A | HOH415 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PT A 306 |
Chain | Residue |
A | GLU139 |
A | MET143 |
A | CL307 |
A | HOH444 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 307 |
Chain | Residue |
A | ALA140 |
A | MET143 |
A | PT306 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 301 |
Chain | Residue |
B | HIS201 |
B | HIS205 |
B | HIS211 |
B | NGH306 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 302 |
Chain | Residue |
B | HIS151 |
B | ASP153 |
B | HIS166 |
B | HIS179 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 303 |
Chain | Residue |
B | ASP158 |
B | GLY159 |
B | GLY161 |
B | VAL163 |
B | ASP181 |
B | GLU184 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 304 |
Chain | Residue |
B | ASP141 |
B | GLY173 |
B | ASN175 |
B | ASP177 |
B | HOH402 |
B | HOH404 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 305 |
Chain | Residue |
B | ASP107 |
B | ASP182 |
B | GLU184 |
B | HOH444 |
B | HOH454 |
site_id | BC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE NGH B 306 |
Chain | Residue |
B | ASN162 |
B | VAL163 |
B | LEU164 |
B | ALA165 |
B | HIS201 |
B | GLU202 |
B | HIS205 |
B | HIS211 |
B | PRO221 |
B | TYR223 |
B | ZN301 |
B | HOH437 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PT B 307 |
Chain | Residue |
B | GLU139 |
B | MET143 |
B | CL309 |
B | HOH440 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PT B 308 |
Chain | Residue |
B | HIS224 |
B | CL310 |
B | CL311 |
B | HOH420 |
site_id | BC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL B 309 |
Chain | Residue |
B | MET143 |
B | PT307 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL B 310 |
Chain | Residue |
B | TYR223 |
B | HIS224 |
B | PT308 |
B | CL311 |
B | HOH420 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL B 311 |
Chain | Residue |
A | GLY88 |
B | HIS224 |
B | PT308 |
B | CL310 |
B | HOH420 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL |
Chain | Residue | Details |
A | VAL198-LEU207 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU202 | |
B | GLU202 | |
site_id | SWS_FT_FI2 |
Number of Residues | 32 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP107 | |
A | GLY173 | |
A | ASN175 | |
A | ASP177 | |
A | HIS179 | |
A | ASP181 | |
A | ASP182 | |
A | GLU184 | |
B | ASP107 | |
B | ASP141 | |
B | HIS151 | |
A | ASP141 | |
B | ASP153 | |
B | ASP158 | |
B | GLY159 | |
B | GLY161 | |
B | VAL163 | |
B | HIS166 | |
B | GLY173 | |
B | ASN175 | |
B | ASP177 | |
B | HIS179 | |
A | HIS151 | |
B | ASP181 | |
B | ASP182 | |
B | GLU184 | |
A | ASP153 | |
A | ASP158 | |
A | GLY159 | |
A | GLY161 | |
A | VAL163 | |
A | HIS166 | |
Chain | Residue | Details |
A | HIS201 | |
A | HIS205 | |
A | HIS211 | |
B | HIS201 | |
B | HIS205 | |
B | HIS211 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 591 |
Chain | Residue | Details |
A | HIS201 | metal ligand |
A | GLU202 | proton acceptor, proton donor |
A | HIS205 | metal ligand |
A | HIS211 | metal ligand |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 591 |
Chain | Residue | Details |
B | HIS201 | metal ligand |
B | GLU202 | proton acceptor, proton donor |
B | HIS205 | metal ligand |
B | HIS211 | metal ligand |