4J9U
Crystal Structure of the TrkH/TrkA potassium transport complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030001 | biological_process | metal ion transport |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0030001 | biological_process | metal ion transport |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| C | 0015379 | molecular_function | potassium:chloride symporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0030001 | biological_process | metal ion transport |
| C | 0030955 | molecular_function | potassium ion binding |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| D | 0015379 | molecular_function | potassium:chloride symporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0030001 | biological_process | metal ion transport |
| D | 0030955 | molecular_function | potassium ion binding |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006813 | biological_process | potassium ion transport |
| E | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| E | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0071805 | biological_process | potassium ion transmembrane transport |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0006813 | biological_process | potassium ion transport |
| F | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| F | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0071805 | biological_process | potassium ion transmembrane transport |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0006813 | biological_process | potassium ion transport |
| G | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| G | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0071805 | biological_process | potassium ion transmembrane transport |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0006813 | biological_process | potassium ion transport |
| H | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| H | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TBR A 501 |
| Chain | Residue |
| A | HIS62 |
| A | PRO151 |
| F | ASP41 |
| F | LYS42 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TBR A 503 |
| Chain | Residue |
| A | ASP423 |
| A | SER426 |
| C | GLU444 |
| D | TBR503 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K A 504 |
| Chain | Residue |
| A | THR112 |
| A | ILE220 |
| A | GLY221 |
| A | THR320 |
| A | ALA321 |
| A | ASN437 |
| A | LEU438 |
| A | THR111 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TBR B 501 |
| Chain | Residue |
| B | LEU150 |
| B | PRO151 |
| G | GLU292 |
| H | LYS42 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE TBR B 502 |
| Chain | Residue |
| B | LEU150 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K B 503 |
| Chain | Residue |
| B | THR111 |
| B | THR112 |
| B | ILE220 |
| B | GLY221 |
| B | THR320 |
| B | ALA321 |
| B | ASN437 |
| B | LEU438 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TBR C 501 |
| Chain | Residue |
| C | PRO151 |
| G | ASP41 |
| G | LYS42 |
| H | GLU292 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE TBR C 502 |
| Chain | Residue |
| C | LEU150 |
| G | ARG46 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K C 503 |
| Chain | Residue |
| C | THR111 |
| C | THR112 |
| C | ILE220 |
| C | GLY221 |
| C | THR320 |
| C | ALA321 |
| C | ASN437 |
| C | LEU438 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TBR D 501 |
| Chain | Residue |
| D | HIS62 |
| D | PRO151 |
| E | ASP41 |
| E | LYS42 |
| F | GLU292 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE TBR D 502 |
| Chain | Residue |
| D | LEU150 |
| D | ILE178 |
| E | ARG46 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TBR D 503 |
| Chain | Residue |
| A | TBR503 |
| B | GLU444 |
| D | ASP423 |
| D | GLU444 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K D 504 |
| Chain | Residue |
| D | THR111 |
| D | THR112 |
| D | ILE220 |
| D | GLY221 |
| D | THR320 |
| D | ALA321 |
| D | ASN437 |
| D | LEU438 |
| site_id | BC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAD E 501 |
| Chain | Residue |
| E | VAL11 |
| E | ARG100 |
| E | PRO125 |
| E | GLU126 |
| E | VAL129 |
| E | GLY239 |
| E | GLY241 |
| E | ASN242 |
| E | ILE243 |
| E | GLU261 |
| E | ARG262 |
| E | ASP283 |
| E | ALA284 |
| E | THR305 |
| E | ASN306 |
| E | GLU307 |
| E | GLN331 |
| E | PRO350 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE TBR E 502 |
| Chain | Residue |
| E | GLU107 |
| H | HIS59 |
| site_id | BC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TBR E 503 |
| Chain | Residue |
| E | GLY13 |
| E | THR14 |
| E | GLU17 |
| E | GLU38 |
| E | LYS42 |
| E | TYR43 |
| E | ARG332 |
| F | GLN287 |
| F | GLU288 |
| site_id | BC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAD F 501 |
| Chain | Residue |
| F | GLY241 |
| F | ASN242 |
| F | ILE243 |
| F | GLU261 |
| F | ARG262 |
| F | ASP283 |
| F | ALA284 |
| F | THR305 |
| F | ASN306 |
| F | GLU307 |
| F | THR310 |
| F | GLN331 |
| F | PRO350 |
| F | VAL11 |
| F | ARG100 |
| F | PRO125 |
| F | GLU126 |
| F | VAL129 |
| F | GLY239 |
| F | GLY240 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE TBR F 502 |
| Chain | Residue |
| F | GLU107 |
| G | HIS59 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TBR F 503 |
| Chain | Residue |
| E | GLU288 |
| F | GLY13 |
| F | THR14 |
| F | GLU17 |
| F | GLU38 |
| F | TYR43 |
| F | ARG332 |
| site_id | CC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NAD G 501 |
| Chain | Residue |
| G | ARG100 |
| G | PRO125 |
| G | GLU126 |
| G | GLY239 |
| G | GLY241 |
| G | ASN242 |
| G | ILE243 |
| G | GLU261 |
| G | ARG262 |
| G | ASP283 |
| G | ALA284 |
| G | THR305 |
| G | ASN306 |
| G | GLU307 |
| G | GLN331 |
| G | PRO350 |
| G | GLN351 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE TBR G 502 |
| Chain | Residue |
| F | HIS59 |
| G | GLU107 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TBR G 503 |
| Chain | Residue |
| G | THR14 |
| G | GLU17 |
| G | GLU38 |
| G | TYR43 |
| G | ARG332 |
| H | GLU288 |
| site_id | CC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAD H 501 |
| Chain | Residue |
| H | VAL11 |
| H | ARG100 |
| H | PRO125 |
| H | GLU126 |
| H | VAL129 |
| H | GLY239 |
| H | GLY241 |
| H | ASN242 |
| H | ILE243 |
| H | GLU261 |
| H | ARG262 |
| H | ASP283 |
| H | ALA284 |
| H | THR305 |
| H | ASN306 |
| H | GLU307 |
| H | GLN331 |
| H | PRO350 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE TBR H 502 |
| Chain | Residue |
| E | HIS59 |
| H | GLU107 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TBR H 503 |
| Chain | Residue |
| G | GLN287 |
| G | GLU288 |
| H | GLU17 |
| H | GLU38 |
| H | TYR43 |
| H | GLN331 |
| H | ARG332 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 136 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | MET1-GLN2 | |
| A | ARG58-LYS65 | |
| A | PRO151-ARG177 | |
| B | ARG58-LYS65 | |
| B | PRO151-ARG177 | |
| C | MET1-GLN2 | |
| C | ARG58-LYS65 | |
| C | PRO151-ARG177 | |
| D | MET1-GLN2 | |
| D | ARG58-LYS65 | |
| D | PRO151-ARG177 | |
| B | MET1-GLN2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 668 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | PHE3-LEU29 | |
| A | GLY36-ASN57 | |
| A | SER66-ILE90 | |
| A | LYS125-LEU150 | |
| A | ILE178-LEU202 | |
| A | PHE276-LYS296 | |
| A | PRO392-ALA419 | |
| B | PHE3-LEU29 | |
| B | GLY36-ASN57 | |
| B | SER66-ILE90 | |
| B | LYS125-LEU150 | |
| B | ILE178-LEU202 | |
| B | PHE276-LYS296 | |
| B | PRO392-ALA419 | |
| C | PHE3-LEU29 | |
| C | GLY36-ASN57 | |
| C | SER66-ILE90 | |
| C | LYS125-LEU150 | |
| C | ILE178-LEU202 | |
| C | PHE276-LYS296 | |
| C | PRO392-ALA419 | |
| D | PHE3-LEU29 | |
| D | GLY36-ASN57 | |
| D | SER66-ILE90 | |
| D | LYS125-LEU150 | |
| D | ILE178-LEU202 | |
| D | PHE276-LYS296 | |
| D | PRO392-ALA419 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 180 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | LEU30-ALA35 | |
| A | VAL116-PRO124 | |
| A | ALA203-MET205 | |
| A | THR225-ASP234 | |
| A | THR325-PRO332 | |
| A | THR420-GLY421 | |
| A | LEU442-ASN453 | |
| B | LEU30-ALA35 | |
| B | VAL116-PRO124 | |
| B | ALA203-MET205 | |
| B | THR225-ASP234 | |
| B | THR325-PRO332 | |
| B | THR420-GLY421 | |
| B | LEU442-ASN453 | |
| C | LEU30-ALA35 | |
| C | VAL116-PRO124 | |
| C | ALA203-MET205 | |
| C | THR225-ASP234 | |
| C | THR325-PRO332 | |
| C | THR420-GLY421 | |
| C | LEU442-ASN453 | |
| D | LEU30-ALA35 | |
| D | VAL116-PRO124 | |
| D | ALA203-MET205 | |
| D | THR225-ASP234 | |
| D | THR325-PRO332 | |
| D | THR420-GLY421 | |
| D | LEU442-ASN453 | |
| A | ALA91 | |
| A | HIS297 | |
| B | ALA91 | |
| B | HIS297 | |
| C | ALA91 | |
| C | HIS297 | |
| D | ALA91 | |
| D | HIS297 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 188 |
| Details | INTRAMEM: Helical; Pore-forming => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | VAL98-LEU109 | |
| A | PRO303-SER318 | |
| A | GLU424-THR434 | |
| B | VAL98-LEU109 | |
| B | PRO207-ILE218 | |
| B | PRO303-SER318 | |
| B | GLU424-THR434 | |
| C | VAL98-LEU109 | |
| C | PRO207-ILE218 | |
| C | PRO303-SER318 | |
| C | GLU424-THR434 | |
| D | VAL98-LEU109 | |
| D | PRO207-ILE218 | |
| D | PRO303-SER318 | |
| D | GLU424-THR434 | |
| A | PRO207-ILE218 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | THR110-THR115 | |
| A | ALA219-SER224 | |
| A | THR319-THR324 | |
| A | MET422-ASP423 | |
| A | LEU435-GLY441 | |
| B | THR110-THR115 | |
| B | ALA219-SER224 | |
| B | THR319-THR324 | |
| B | MET422-ASP423 | |
| B | LEU435-GLY441 | |
| C | THR110-THR115 | |
| C | ALA219-SER224 | |
| C | THR319-THR324 | |
| C | MET422-ASP423 | |
| C | LEU435-GLY441 | |
| D | THR110-THR115 | |
| D | ALA219-SER224 | |
| D | THR319-THR324 | |
| D | MET422-ASP423 | |
| D | LEU435-GLY441 | |
| A | THR206 | |
| A | CYS251 | |
| A | PHE466 | |
| B | THR206 | |
| B | CYS251 | |
| B | PHE466 | |
| C | THR206 | |
| C | CYS251 | |
| C | PHE466 | |
| D | THR206 | |
| D | CYS251 | |
| D | PHE466 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 152 |
| Details | INTRAMEM: Helical => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | SER235-ALA250 | |
| A | LEU333-PHE344 | |
| A | ASP454-LEU465 | |
| B | SER235-ALA250 | |
| B | LEU333-PHE344 | |
| B | ASP454-LEU465 | |
| C | SER235-ALA250 | |
| C | LEU333-PHE344 | |
| C | ASP454-LEU465 | |
| D | SER235-ALA250 | |
| D | LEU333-PHE344 | |
| D | ASP454-LEU465 | |
| A | VAL358 | |
| B | VAL358 | |
| C | VAL358 | |
| D | VAL358 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 48 |
| Details | INTRAMEM: Note=Loop between two helices => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | ILE345-LYS357 | |
| B | ILE345-LYS357 | |
| C | ILE345-LYS357 | |
| D | ILE345-LYS357 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21317882 |
| Chain | Residue | Details |
| A | THR111 | |
| A | THR112 | |
| A | ILE220 | |
| A | GLY221 | |
| A | THR320 | |
| A | ALA321 | |
| A | ASN437 | |
| A | LEU438 | |
| B | THR111 | |
| B | THR112 | |
| B | ILE220 | |
| B | GLY221 | |
| B | THR320 | |
| B | ALA321 | |
| B | ASN437 | |
| B | LEU438 | |
| C | THR111 | |
| C | THR112 | |
| C | ILE220 | |
| C | GLY221 | |
| C | THR320 | |
| C | ALA321 | |
| C | ASN437 | |
| C | LEU438 | |
| D | THR111 | |
| D | THR112 | |
| D | ILE220 | |
| D | GLY221 | |
| D | THR320 | |
| D | ALA321 | |
| D | ASN437 | |
| D | LEU438 |
