4J28
Crystal structure of a gh29 alpha-l-fucosidase gh29 from bacteroides thetaiotaomicron in complex with a 5-membered iminocyclitol inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004560 | molecular_function | alpha-L-fucosidase activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0015928 | molecular_function | fucosidase activity |
| A | 0016139 | biological_process | glycoside catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0004560 | molecular_function | alpha-L-fucosidase activity |
| B | 0005764 | cellular_component | lysosome |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006004 | biological_process | fucose metabolic process |
| B | 0015928 | molecular_function | fucosidase activity |
| B | 0016139 | biological_process | glycoside catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EAT A 501 |
| Chain | Residue |
| A | HIS66 |
| A | IMD505 |
| A | GLU87 |
| A | TRP88 |
| A | HIS135 |
| A | HIS136 |
| A | TYR178 |
| A | ASP229 |
| A | TRP232 |
| A | TRP316 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD A 502 |
| Chain | Residue |
| A | ALA63 |
| A | TRP117 |
| A | MET120 |
| A | TYR168 |
| A | PHE359 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD A 503 |
| Chain | Residue |
| A | TRP88 |
| A | HOH720 |
| A | HOH990 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD A 504 |
| Chain | Residue |
| A | GLU288 |
| A | THR310 |
| A | GLU313 |
| A | ASN314 |
| A | TRP316 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD A 505 |
| Chain | Residue |
| A | TRP232 |
| A | EAT501 |
| A | SO4507 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IMD A 506 |
| Chain | Residue |
| A | ARG399 |
| A | VAL405 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 507 |
| Chain | Residue |
| A | TRP232 |
| A | ARG262 |
| A | ARG271 |
| A | HIS272 |
| A | IMD505 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 508 |
| Chain | Residue |
| A | LYS90 |
| A | ALA97 |
| A | HOH806 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 509 |
| Chain | Residue |
| A | LYS145 |
| A | GLU215 |
| A | THR218 |
| A | HOH707 |
| B | GLU252 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 510 |
| Chain | Residue |
| A | ASN169 |
| A | GLY172 |
| A | ASP174 |
| A | LYS224 |
| A | HOH621 |
| A | HOH917 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EAT B 501 |
| Chain | Residue |
| B | HIS66 |
| B | GLU87 |
| B | TRP88 |
| B | HIS135 |
| B | HIS136 |
| B | TYR178 |
| B | TRP227 |
| B | ASP229 |
| B | TRP232 |
| B | TRP316 |
| B | HOH792 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IMD B 502 |
| Chain | Residue |
| B | TRP117 |
| B | MET120 |
| B | TYR168 |
| B | PHE359 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 503 |
| Chain | Residue |
| B | TRP232 |
| B | ARG262 |
| B | ARG271 |
| B | HIS272 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 504 |
| Chain | Residue |
| B | GLU416 |
| B | VAL454 |
| B | PRO455 |
| B | LYS456 |
| B | ASN458 |
| B | HOH620 |
| B | HOH839 |
| B | HOH840 |
| B | HOH897 |
