4J0N
Crystal structure of a manganese dependent isatin hydrolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004061 | molecular_function | arylformamidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| A | 0019441 | biological_process | L-tryptophan catabolic process to kynurenine |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004061 | molecular_function | arylformamidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| B | 0019441 | biological_process | L-tryptophan catabolic process to kynurenine |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 301 |
| Chain | Residue |
| A | HIS73 |
| A | HIS77 |
| A | ASP79 |
| A | HOH473 |
| A | HOH520 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 302 |
| Chain | Residue |
| A | PHE41 |
| A | PHE209 |
| B | PHE62 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 301 |
| Chain | Residue |
| B | GLN201 |
| B | HOH477 |
| B | HOH478 |
| B | HOH489 |
| B | HOH528 |
| A | GLN201 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 302 |
| Chain | Residue |
| B | HIS73 |
| B | HIS77 |
| B | ASP79 |
| B | HOH507 |
| B | HOH508 |
| B | HOH529 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 303 |
| Chain | Residue |
| A | PHE62 |
| A | PHE63 |
| B | PHE41 |
| B | PHE209 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA B 304 |
| Chain | Residue |
| A | HOH509 |
| B | TRP67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"24917679","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24917679","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24917679","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4J0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24917679","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4M8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
