4J07

Crystal structure of a PROBABLE RIBOFLAVIN SYNTHASE, BETA CHAIN RIBH (6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, Lumazine synthase) from Mycobacterium leprae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
A	0005829	cellular_component	cytosol
A	0009231	biological_process	riboflavin biosynthetic process
A	0009349	cellular_component	riboflavin synthase complex
A	0016740	molecular_function	transferase activity
B	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
B	0005829	cellular_component	cytosol
B	0009231	biological_process	riboflavin biosynthetic process
B	0009349	cellular_component	riboflavin synthase complex
B	0016740	molecular_function	transferase activity
C	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
C	0005829	cellular_component	cytosol
C	0009231	biological_process	riboflavin biosynthetic process
C	0009349	cellular_component	riboflavin synthase complex
C	0016740	molecular_function	transferase activity
D	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
D	0005829	cellular_component	cytosol
D	0009231	biological_process	riboflavin biosynthetic process
D	0009349	cellular_component	riboflavin synthase complex
D	0016740	molecular_function	transferase activity
E	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
E	0005829	cellular_component	cytosol
E	0009231	biological_process	riboflavin biosynthetic process
E	0009349	cellular_component	riboflavin synthase complex
E	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 201

Chain	Residue
A	ALA70
A	HIS73
A	THR110
A	HOH327
A	HOH363
A	HOH375

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	HOH309
A	HOH340
B	ARG128
D	LYS123
A	GLY85
A	ASP86
A	THR87

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 201

Chain	Residue
B	ALA70
B	HIS73
B	THR110
B	HOH344
B	HOH353
B	HOH366

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 202

Chain	Residue
B	ASP86
B	THR87
B	HOH345
C	LYS123
E	ARG128
E	HOH327

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 201

Chain	Residue
C	ALA70
C	HIS73
C	THR110
C	HOH309
C	HOH328
C	HOH393

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 202

Chain	Residue
B	LYS123
C	GLY85
C	ASP86
C	THR87
C	HOH347
C	HOH369
D	ARG128
D	HOH384

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 201

Chain	Residue
A	LYS123
A	ARG128
D	ASP86
D	THR87
D	HOH357
D	HOH370

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D 202

Chain	Residue
A	ASN95
A	GLN99
B	ASN95
C	ASN95
C	GLN99
D	ASN95
D	GLN99
E	ASN95
E	GLN99

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 203

Chain	Residue
D	ALA70
D	HIS73
D	THR110
D	HOH326
D	HOH329
D	HOH334

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E 201

Chain	Residue
C	ARG128
E	GLY85
E	ASP86
E	THR87
E	LYS123
E	HOH324
E	HOH343

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 202

Chain	Residue
E	ALA70
E	HIS73
E	THR110
E	HOH316
E	HOH328
E	HOH369

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00178

Chain	Residue	Details
A	HIS89
B	HIS89
C	HIS89
D	HIS89
E	HIS89

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00178

Chain	Residue	Details
A	ARG128
B	TRP27
B	ALA59
B	VAL81
B	ASP86
B	ASN114
B	ARG128
C	TRP27
C	ALA59
C	VAL81
C	ASP86
C	ASN114
C	ARG128
D	TRP27
D	ALA59
D	VAL81
D	ASP86
D	ASN114
D	ARG128
E	TRP27
E	ALA59
E	VAL81
E	ASP86
E	ASN114
E	ARG128
A	TRP27
A	ALA59
A	VAL81
A	ASP86
A	ASN114

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