Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | ASP246 |
| A | ASP250 |
| A | HOH660 |
| A | HOH733 |
| B | ASP222 |
| B | HOH559 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | ASP250 |
| B | HOH672 |
| B | HOH757 |
| B | HOH759 |
| A | ASP222 |
| A | HOH734 |
| B | ASP246 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NMFGDIlSDeaSmlt.GSIGM |
| Chain | Residue | Details |
| A | ASN242-MET261 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ARG128 | |
| A | ASP222 | |
| A | ASP246 | |
| A | ASP250 | |
| A | GLY280 | |
| B | ARG90 | |
| B | ARG100 | |
| B | ARG128 | |
| B | ASP222 | |
| B | ASP246 | |
| B | ASP250 | |
| B | GLY280 | |
| A | ARG90 | |
| A | ARG100 | |
| Chain | Residue | Details |
| A | TYR135 | |
| A | LYS190 | |
| B | TYR135 | |
| B | LYS190 | |
