4IW4
Crystal structure of the serine protease domain of MASP-3 in complex with ecotin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0006952 | biological_process | defense response |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0030414 | molecular_function | peptidase inhibitor activity |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0006952 | biological_process | defense response |
| D | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| D | 0030414 | molecular_function | peptidase inhibitor activity |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0042803 | molecular_function | protein homodimerization activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
Functional Information from PROSITE/UniProt
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DTclGDSGGAFV |
| Chain | Residue | Details |
| E | ASP639-VAL650 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Reactive bond","evidences":[{"source":"PubMed","id":"35483450","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19564340","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19564340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23386610","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
