4IV5

X-ray crystal structure of a putative aspartate carbamoyltransferase from Trypanosoma cruzi

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004070	molecular_function	aspartate carbamoyltransferase activity
D	0005829	cellular_component	cytosol
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
E	0004070	molecular_function	aspartate carbamoyltransferase activity
E	0005829	cellular_component	cytosol
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
F	0004070	molecular_function	aspartate carbamoyltransferase activity
F	0005829	cellular_component	cytosol
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 401

Chain	Residue
A	SER62
A	SER63
A	ARG64
A	THR65
A	ARG113
A	LEU289
A	HOH523
B	SER89
B	LYS92

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 401

Chain	Residue
B	SER62
B	ARG64
B	THR65
B	ARG113
B	HIS141
B	LEU289
B	HOH587

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 C 401

Chain	Residue
C	SER62
C	SER63
C	ARG64
C	THR65
C	ARG113
C	LEU289
C	PRO290
C	HOH658
D	SER89

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 D 500

Chain	Residue
D	SER62
D	SER63
D	ARG64
D	THR65
D	ARG113
D	LEU289

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 E 401

Chain	Residue
C	SER89
E	SER62
E	SER63
E	ARG64
E	THR65
E	ARG113
E	LEU289
E	PRO290
E	HOH632

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 402

Chain	Residue
B	GLY218
E	SER9
E	LYS13
E	GLN20
E	ASP25
E	HOH569

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 F 401

Chain	Residue
A	SER89
F	SER62
F	SER63
F	ARG64
F	THR65
F	ARG113
F	LEU289

---