4IUA

Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE A 1001

Chain	Residue
A	PHE163
A	GLY186
A	GLY187
A	TRP189
A	PHE191
A	ARG198
A	VAL201
E	SER162

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	GLY170
A	LYS171
A	ASP172
A	ARG169

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	LYS231
A	THR232
A	LEU275
A	ASP276

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE B 1001

Chain	Residue
B	PHE163
B	GLU184
B	GLY186
B	GLY187
B	TRP189
B	PHE191
B	ARG198
B	TYR199

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1002

Chain	Residue
B	LYS63
B	LYS64
B	ARG96

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 1003

Chain	Residue
B	TYR168
B	ARG169
B	GLY170
B	LYS171
B	ASP172
B	LEU173
B	GLN174

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1004

Chain	Residue
B	LYS231
B	THR232
B	ASP276

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EPE B 1005

Chain	Residue
B	ARG198
B	TYR199
E	SER166
E	ARG169

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE C 1001

Chain	Residue
C	PHE163
C	ARG182
C	GLU184
C	GLY186
C	GLY187
C	TRP189
C	PHE191
C	ARG198
C	TYR199

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EPE C 1002

Chain	Residue
C	SER166
C	ARG169

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1003

Chain	Residue
C	ARG169
C	GLY170
C	ASP172
C	LEU173
C	GLN174

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EPE D 1001

Chain	Residue
D	PHE163
D	GLY187
D	TRP189
D	PHE191
D	ARG198
D	TYR199

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 1002

Chain	Residue
D	ARG94
D	ARG96

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1003

Chain	Residue
D	THR84
D	GLY170
D	LYS171
D	ASP172
D	GLN174

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1004

Chain	Residue
D	LYS231
D	THR232
D	LEU275
D	ASP276

---

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE E 1001

Chain	Residue
A	SER162
E	PHE163
E	GLU184
E	GLY186
E	GLY187
E	TRP189
E	PHE191
E	ARG198
E	TYR199

---

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE F 1001

Chain	Residue
F	PHE163
F	GLU184
F	GLY186
F	GLY187
F	TRP189
F	PHE191
F	ARG198
F	TYR199
G	SER162

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 1002

Chain	Residue
F	LYS64
F	ARG94

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 1003

Chain	Residue
F	GLN174
D	GLU196
F	ARG169
F	GLY170
F	ASP172
F	LEU173

---

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 1004

Chain	Residue
F	LYS231
F	THR232

---

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPE G 1001

Chain	Residue
F	SER162
G	PHE163
G	GLU184
G	GLY186
G	GLY187
G	TRP189
G	PHE191
G	ARG198
G	TYR199

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 G 1002

Chain	Residue
G	THR84
G	ARG169
G	GLY170
G	LYS171
G	ASP172
G	GLN174

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 1003

Chain	Residue
G	LYS231
G	THR232
G	LEU275
G	ASP276

---

site_id	CC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE H 1001

Chain	Residue
H	PHE163
H	GLU184
H	GLY186
H	GLY187
H	TRP189
H	PHE191
H	ARG198
H	TYR199

---

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 1002

Chain	Residue
H	ARG169
H	GLY170
H	ASP172

---

Functional Information from PROSITE/UniProt

site_id	PS00021
Number of Residues	14
Details	KRINGLE_1 Kringle domain signature. YCRNprgeeggpWC

Chain	Residue	Details
A	TYR177-CYS190
A	TYR260-CYS272

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	516
Details	Domain: {"description":"PAN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00315","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	624
Details	Domain: {"description":"Kringle 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	616
Details	Domain: {"description":"Kringle 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---