4ITR

Crystal Structure of IbpAFic2-H3717A in complex with adenylylated Cdc42

Replaces:  3N3V

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0000322	cellular_component	storage vacuole
C	0003015	biological_process	heart process
C	0003253	biological_process	cardiac neural crest cell migration involved in outflow tract morphogenesis
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005911	cellular_component	cell-cell junction
C	0005925	cellular_component	focal adhesion
C	0006897	biological_process	endocytosis
C	0006911	biological_process	phagocytosis, engulfment
C	0007015	biological_process	actin filament organization
C	0007030	biological_process	Golgi organization
C	0007163	biological_process	establishment or maintenance of cell polarity
C	0007165	biological_process	signal transduction
C	0007229	biological_process	integrin-mediated signaling pathway
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0007399	biological_process	nervous system development
C	0009653	biological_process	anatomical structure morphogenesis
C	0010591	biological_process	regulation of lamellipodium assembly
C	0010592	biological_process	positive regulation of lamellipodium assembly
C	0015630	cellular_component	microtubule cytoskeleton
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0017119	cellular_component	Golgi transport complex
C	0019901	molecular_function	protein kinase binding
C	0021762	biological_process	substantia nigra development
C	0030010	biological_process	establishment of cell polarity
C	0030036	biological_process	actin cytoskeleton organization
C	0030154	biological_process	cell differentiation
C	0030175	cellular_component	filopodium
C	0030225	biological_process	macrophage differentiation
C	0030307	biological_process	positive regulation of cell growth
C	0030335	biological_process	positive regulation of cell migration
C	0030425	cellular_component	dendrite
C	0030496	cellular_component	midbody
C	0030742	molecular_function	GTP-dependent protein binding
C	0031252	cellular_component	cell leading edge
C	0031256	cellular_component	leading edge membrane
C	0031274	biological_process	positive regulation of pseudopodium assembly
C	0031333	biological_process	negative regulation of protein-containing complex assembly
C	0031996	molecular_function	thioesterase binding
C	0032427	molecular_function	GBD domain binding
C	0032467	biological_process	positive regulation of cytokinesis
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0032991	cellular_component	protein-containing complex
C	0034191	molecular_function	apolipoprotein A-I receptor binding
C	0034329	biological_process	cell junction assembly
C	0035050	biological_process	embryonic heart tube development
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0038189	biological_process	neuropilin signaling pathway
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0044788	biological_process	host-mediated perturbation of viral process
C	0045177	cellular_component	apical part of cell
C	0045198	biological_process	establishment of epithelial cell apical/basal polarity
C	0045335	cellular_component	phagocytic vesicle
C	0048549	biological_process	positive regulation of pinocytosis
C	0051130	biological_process	positive regulation of cellular component organization
C	0051233	cellular_component	spindle midzone
C	0051489	biological_process	regulation of filopodium assembly
C	0051491	biological_process	positive regulation of filopodium assembly
C	0051492	biological_process	regulation of stress fiber assembly
C	0051496	biological_process	positive regulation of stress fiber assembly
C	0051683	biological_process	establishment of Golgi localization
C	0051988	biological_process	regulation of attachment of spindle microtubules to kinetochore
C	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
C	0060501	biological_process	positive regulation of epithelial cell proliferation involved in lung morphogenesis
C	0060997	biological_process	dendritic spine morphogenesis
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070062	cellular_component	extracellular exosome
C	0071944	cellular_component	cell periphery
C	0072384	biological_process	organelle transport along microtubule
C	0072686	cellular_component	mitotic spindle
C	0086100	biological_process	endothelin receptor signaling pathway
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099175	biological_process	regulation of postsynapse organization
C	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0000322	cellular_component	storage vacuole
D	0003015	biological_process	heart process
D	0003253	biological_process	cardiac neural crest cell migration involved in outflow tract morphogenesis
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005911	cellular_component	cell-cell junction
D	0005925	cellular_component	focal adhesion
D	0006897	biological_process	endocytosis
D	0006911	biological_process	phagocytosis, engulfment
D	0007015	biological_process	actin filament organization
D	0007030	biological_process	Golgi organization
D	0007163	biological_process	establishment or maintenance of cell polarity
D	0007165	biological_process	signal transduction
D	0007229	biological_process	integrin-mediated signaling pathway
D	0007264	biological_process	small GTPase-mediated signal transduction
D	0007399	biological_process	nervous system development
D	0009653	biological_process	anatomical structure morphogenesis
D	0010591	biological_process	regulation of lamellipodium assembly
D	0010592	biological_process	positive regulation of lamellipodium assembly
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0017119	cellular_component	Golgi transport complex
D	0019901	molecular_function	protein kinase binding
D	0021762	biological_process	substantia nigra development
D	0030010	biological_process	establishment of cell polarity
D	0030036	biological_process	actin cytoskeleton organization
D	0030154	biological_process	cell differentiation
D	0030175	cellular_component	filopodium
D	0030225	biological_process	macrophage differentiation
D	0030307	biological_process	positive regulation of cell growth
D	0030335	biological_process	positive regulation of cell migration
D	0030425	cellular_component	dendrite
D	0030496	cellular_component	midbody
D	0030742	molecular_function	GTP-dependent protein binding
D	0031252	cellular_component	cell leading edge
D	0031256	cellular_component	leading edge membrane
D	0031274	biological_process	positive regulation of pseudopodium assembly
D	0031333	biological_process	negative regulation of protein-containing complex assembly
D	0031996	molecular_function	thioesterase binding
D	0032427	molecular_function	GBD domain binding
D	0032467	biological_process	positive regulation of cytokinesis
D	0032956	biological_process	regulation of actin cytoskeleton organization
D	0032991	cellular_component	protein-containing complex
D	0034191	molecular_function	apolipoprotein A-I receptor binding
D	0034329	biological_process	cell junction assembly
D	0035050	biological_process	embryonic heart tube development
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0038189	biological_process	neuropilin signaling pathway
D	0042802	molecular_function	identical protein binding
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0044788	biological_process	host-mediated perturbation of viral process
D	0045177	cellular_component	apical part of cell
D	0045198	biological_process	establishment of epithelial cell apical/basal polarity
D	0045335	cellular_component	phagocytic vesicle
D	0048549	biological_process	positive regulation of pinocytosis
D	0051130	biological_process	positive regulation of cellular component organization
D	0051233	cellular_component	spindle midzone
D	0051489	biological_process	regulation of filopodium assembly
D	0051491	biological_process	positive regulation of filopodium assembly
D	0051492	biological_process	regulation of stress fiber assembly
D	0051496	biological_process	positive regulation of stress fiber assembly
D	0051683	biological_process	establishment of Golgi localization
D	0051988	biological_process	regulation of attachment of spindle microtubules to kinetochore
D	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
D	0060501	biological_process	positive regulation of epithelial cell proliferation involved in lung morphogenesis
D	0060997	biological_process	dendritic spine morphogenesis
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0070062	cellular_component	extracellular exosome
D	0071944	cellular_component	cell periphery
D	0072384	biological_process	organelle transport along microtubule
D	0072686	cellular_component	mitotic spindle
D	0086100	biological_process	endothelin receptor signaling pathway
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0099175	biological_process	regulation of postsynapse organization
D	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 3801

Chain	Residue
A	ARG3660
A	LEU3661
A	HOH4112
A	HOH4113
A	HOH4117
B	LYS3532

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 3801

Chain	Residue
B	HOH4034
B	HOH4080
B	HOH4088
A	LYS3532
B	ARG3660
B	LEU3661

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AMP C 201

Chain	Residue
B	LYS3670
B	GLU3671
B	ALA3673
B	ILE3714
B	GLU3721
B	GLY3722
B	ASN3723
B	GLY3724
B	ARG3728
B	GLU3751
B	PRO3752
B	ILE3755
B	GLN3757
B	HOH4137
C	TYR32
C	HOH324

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GDP C 202

Chain	Residue
B	GLU3671
B	ASN3672
C	ALA13
C	VAL14
C	GLY15
C	LYS16
C	THR17
C	CYS18
C	PHE28
C	GLN116
C	ASP118
C	LEU119
C	SER158
C	ALA159
C	LEU160
C	MG203
C	HOH302
C	HOH305
C	HOH308
C	HOH316
C	HOH328
C	HOH342
C	HOH345

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 203

Chain	Residue
C	THR17
C	THR35
C	GDP202
C	HOH302
C	HOH345

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 204

Chain	Residue
B	LYS3759
B	SER3761
B	HOH4138
B	HOH4143
C	SER86
C	PRO87
C	SER88
C	GLN134
C	HOH404

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AMP D 201

Chain	Residue
A	LYS3670
A	GLU3671
A	ALA3673
A	ILE3714
A	GLU3721
A	GLY3722
A	ASN3723
A	GLY3724
A	ARG3728
A	GLU3751
A	PRO3752
A	ILE3755
A	GLN3757
A	HOH4118
D	TYR32
D	HOH366

---

site_id	AC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GDP D 202

Chain	Residue
D	HOH306
D	HOH308
D	HOH312
D	HOH330
D	HOH340
D	HOH387
D	HOH395
A	GLU3671
A	ASN3672
D	ASP11
D	ALA13
D	VAL14
D	GLY15
D	LYS16
D	THR17
D	CYS18
D	PHE28
D	GLN116
D	ASP118
D	LEU119
D	SER158
D	ALA159
D	LEU160
D	MG203
D	HOH302

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 203

Chain	Residue
D	THR17
D	THR35
D	GDP202
D	HOH302
D	HOH340
D	HOH387

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D 204

Chain	Residue
A	LYS3759
A	SER3761
D	SER86
D	PRO87
D	SER88
D	GLN134
D	HOH381
D	HOH389
D	HOH402

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	Domain: {"description":"Fido 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00791","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Region: {"description":"Arm region"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622875","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"14506284","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---