4IS2
Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0006699 | biological_process | bile acid biosynthetic process |
A | 0008202 | biological_process | steroid metabolic process |
A | 0008206 | biological_process | bile acid metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0030573 | biological_process | bile acid catabolic process |
A | 0032052 | molecular_function | bile acid binding |
A | 0033764 | molecular_function | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0033792 | molecular_function | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity |
A | 0051289 | biological_process | protein homotetramerization |
A | 0070403 | molecular_function | NAD+ binding |
A | 1903412 | biological_process | response to bile acid |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 301 |
Chain | Residue |
A | TYR54 |
A | PRO55 |
A | GLU56 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvtgifgslsGvgYPASKASViGLThGLG |
Chain | Residue | Details |
A | SER144-GLY172 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU10001, ECO:0000305|PubMed:23836456 |
Chain | Residue | Details |
A | TYR157 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:23836456 |
Chain | Residue | Details |
A | LYS161 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23836456, ECO:0007744|PDB:4IS3 |
Chain | Residue | Details |
A | THR15 | |
A | GLU38 | |
A | GLU42 | |
A | ASN92 | |
A | LYS161 | |
A | VAL190 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER144 |