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4IOR

Crystal Structure of the first bromodomain of BRD4 in complex with DMSO

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 301
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 302
ChainResidue
AILE138
AGLN159
ALYS160
AHOH552

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 303
ChainResidue
AHIS77
AASN130
ATHR134
AHOH451
AHOH473
AHOH549

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 304
ChainResidue
APRO53
ATRP81
ALYS99
AILE146
AMET149
AHOH540
AHOH551

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE DMS A 305
ChainResidue
APRO82
AASN140
AHOH409

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

226707

PDB entries from 2024-10-30

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